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Thiazides may be especially useful to treat hypertension from calcineurin-inhibitor drugs. |
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Health Canal: Calcineurin inhibitors, which can be instrumental in preventing organ rejection in transplant patients, also can cause hypertension and kidney problems. The researchers’ findings reveal what ultimately causes those problems — a calcineurin inhibitor spurs the production of an abnormally high level of a natural protein in the kidney. Researchers found that a thiazide diuretic drug, which blocks the responsible protein, reduced hypertension in mice that had been given the calcineurin inhibitor. And mice lacking this protein did not develop hypertension at all.
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