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Sulodexide fails to show benefit in diabetic kidney disease in large trial. |
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EurekAlert (JASN): To test the effects of sulodexide on the kidneys in a large and extensive trial, David Packham, MD (Melbourne Renal Research Group, in Australia) and his colleagues within the Collaborative Study Group (a large clinical trial group comprised of various kidney care centers) conducted a randomized, double-blind, placebo-controlled study in patients with diabetes and kidney disease. The investigators planned to enroll 2,240 patients in the Sun-MACRO trial over a period of two years, but they stopped the study early after enrolling 1,248 patients because they did not detect any significant differences between sulodexide and placebo for preventing kidney failure. Also, the trial did not confirm the potentially beneficial effect of sulodexide in reducing urinary protein excretion that was previously reported in smaller studies.
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