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CKD may cause breakdown of tight junctions between intestinal epithelial cells. |
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EurekAlert: Dr. N.D. Vaziri, professor emeritus of medicine and physiology & biophysics, found that CKD causes massive depletion of the key adhesive proteins, called the tight junction, that normally seal the space between the cells lining the intestines. This breakdown in the colon allows the leakage of microbial products and other noxious material into the body's internal environment, accounting for the persistent systemic inflammation that frequently occurs in CKD patients.
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