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k i d n e y + a u g m e n t + i n + f o u r + d i f f e r e n t + p r e c l i n i c a l + m o d e l s + o f + c k d + t w o + o f + t h e s e + p r e c l i n i c a l + m o d e l s + h a v e + b e e n + c o n d u c t e d + f o r + a + s u f f i c i e n t l y + l o n g + p e r i o d + o f + t i m e + t o + d e m o n s t r a t e + d u r a b i l i t y + a n d + a n + i m p a c t + o n + s u r v i v a l + t e n g i o n + a n t i c i p a t e s + s u b m i t t i n g + a n + i n d + f i l i n g + f o r + t h e + n e o - k i d n e y + a u g m e n t + t o + f d a + d u r i n g + t h e + f i r s t + h a l f + o f + 2 0 1 3 + t e n g i o n + i s + a l s o + e x p l o r i n g + m o v i n g + f o r w a r d + u s i n g + t h e + a d v a n c e d + t h e r a p y + m e d i c i n a l + p r o d u c t s + % 2 8 a t m p % 2 9 + p a t h w a y % 2 c + a n + e s t a b l i s h e d + r e g u l a t o r y + r o u t e + i n + e u r o p e + f o r + a d v a n c e d + c e l l - b a s e d + t h e r a p i e s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + t h e + n e o - u r i n a r y + c o n d u i t % 2 8 t m % 2 9 t h e + n e o - u r i n a r y + c o n d u i t % 2 8 t m % 2 9 + i s + a + c o m b i n a t i o n + o f + a + p a t i e n t % 2 7 s + o w n + c e l l s + a n d + b i o a b s o r b a b l e + s c a f f o l d + t h a t + i s + i n t e n d e d + t o + c a t a l y z e + r e g e n e r a t i o n + o f + a + n a t i v e - l i k e + u r i n a r y + t i s s u e + c o n d u i t % 2 c + p a s s i v e l y + t r a n s p o r t i n g + u r i n e + f r o m + t h e + u r e t e r s + t h r o u g h + a + s t o m a % 2 c + o r + h o l e + i n + t h e + a b d o m e n % 2 c + i n t o + a + s t a n d a r d + o s t o m y + b a g + s t a n d a r d + o f + c a r e + f o r + p a t i e n t s + r e q u i r i n g + a + n o n - c o n t i n e n t + u r i n a r y + d i v e r s i o n + u s e s + b o w e l + t i s s u e + t o + c o n s t r u c t + a + c o n d u i t + f o r + u r i n e + t o + e x i t + f r o m + t h e + b o d y + t h e r e + a r e + o v e r + 2 0 % 2 c 0 0 0 + u r i n a r y + d i v e r s i o n s + p e r f o r m e d + a n n u a l l y + i n + t h e + u n i t e d + s t a t e s + a n d + e u r o p e + t h e s e + p a t i e n t s + a r e + a t + r i s k + f o r + c o m p l i c a t i o n s + a s s o c i a t e d + w i t h + t h e + u s e + o f + b o w e l + t i s s u e % 2 c + a s + w e l l + a s + f o r + t h o s e + a s s o c i a t e d + w i t h + t h e + s u r g e r y + t o + h a r v e s t + t h e + b o w e l + t i s s u e + t h e + n e o - u r i n a r y + c o n d u i t + i s + t h e + o n l y + p r o d u c t + c a n d i d a t e + c u r r e n t l y + i n + d e v e l o p m e n t + t h a t + a i m s + t o + a v o i d + t h e + u s e + o f + b o w e l + t i s s u e + t h e + n e o - u r i n a r y + c o n d u i t + i s + b e i n g + e v a l u a t e d + i n + a n + o n g o i n g + p h a s e + 1 + c l i n i c a l + t r i a l + i n + b l a d d e r + c a n c e r + p a t i e n t s + r e q u i r i n g + a + u r i n a r y + d i v e r s i o n + f o l l o w i n g + b l a d d e r + r e m o v a l + % 2 8 c y s t e c t o m y % 2 9 + t h e + t r i a l + i s + d e s i g n e d + t o + a s s e s s + t h e + s a f e t y + a n d + p r e l i m i n a r y + e f f i c a c y + o f + t h e + n e o - u r i n a r y + c o n d u i t + i n + u p + t o + 1 0 + p a t i e n t s % 2 c + a s + w e l l + a s + t o + t r a n s l a t e + t h e + s u r g i c a l + p r o c e d u r e + s u c c e s s f u l l y + u s e d + i n + p r e c l i n i c a l + a n i m a l + m o d e l s + i n t o + c l i n i c a l + t r i a l s + w i t h + h u m a n + p a t i e n t s + + f o u r + p a t i e n t s + h a v e + b e e n + e n r o l l e d + t o + d a t e + i n + t h e + t r i a l + a t + t h e + u n i v e r s i t y + o f + c h i c a g o + m e d i c a l + c e n t e r + a n d + a t + t h e + j o h n s + h o p k i n s + h o s p i t a l + i n + b a l t i m o r e % 2 c + m a r y l a n d + t h e + c o m p a n y + e x p e c t s + t o + c o m p l e t e + i m p l a n t a t i o n + o f + t h e + r e m a i n i n g + p a t i e n t s + i n + t h e + t r i a l + b y + t h e + e n d + o f + 2 0 1 2 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + t e n g i o n t e n g i o n % 2 c + a + c l i n i c a l - s t a g e + r e g e n e r a t i v e + m e d i c i n e + c o m p a n y % 2 c + i s + f o c u s e d + o n + d e v e l o p i n g + i t s + o r g a n + r e g e n e r a t i o n + p l a t f o r m % 2 8 t m % 2 9 % 2 c + t o + h a r n e s s + t h e + i n t r i n s i c + r e g e n e r a t i v e + p a t h w a y s + o f + t h e + b o d y + t o + r e g e n e r a t e + a + r a n g e + o f + n a t i v e - l i k e + o r g a n s + a n d + t i s s u e s + a n d + d e l a y + o r + e l i m i n a t e + t h e + n e e d + f o r + c h r o n i c + d i s e a s e + t h e r a p i e s % 2 c + o r g a n + t r a n s p l a n t a t i o n % 2 c + a n d + t h e + a d m i n i s t r a t i o n + o f + a n t i - r e j e c t i o n + m e d i c a t i o n s + a n + i n i t i a l + c l i n i c a l + t r i a l + i s + o n g o i n g + f o r + t h e + c o m p a n y % 2 7 s + l e a d + p r o d u c t + c a n d i d a t e % 2 c + t h e + n e o - u r i n a r y + c o n d u i t % 2 8 t m % 2 9 % 2 c + a n + a u t o l o g o u s + i m p l a n t + t h a t + i s + i n t e n d e d + t o + c a t a l y z e + r e g e n e r a t i o n + o f + n a t i v e - l i k e + u r i n a r y + t i s s u e + f o r + b l a d d e r + c a n c e r + p a t i e n t s + r e q u i r i n g + a + u r i n a r y + d i v e r s i o n + f o l l o w i n g + b l a d d e r + r e m o v a l + t h e + c o m p a n y % 2 7 s + l e a d + p r e c l i n i c a l + c a n d i d a t e + i s + t h e + n e o - k i d n e y + a u g m e n t % 2 8 t m % 2 9 % 2 c + w h i c h + i s + d e s i g n e d + t o + p r e v e n t + o r + d e l a y + d i a l y s i s + k i d n e y + t r a n s p l a n t a t i o n + b y + i n c r e a s i n g + r e n a l + f u n c t i o n + i n + p a t i e n t s + w i t h + a d v a n c e d + c h r o n i c + k i d n e y + d i s e a s e + t e n g i o n + h a s + w o r l d w i d e + r i g h t s + t o + i t s + p r o d u c t + c a n d i d a t e s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a f o r w a r d - l o o k i n g + s t a t e m e n t s c e r t a i n + s t a t e m e n t s + s e t + f o r t h + a b o v e + m a y + c o n s t i t u t e + f o r w a r d - l o o k i n g + s t a t e m e n t s + w i t h i n + t h e + m e a n i n g + o f + t h e + p r i v a t e + s e c u r i t i e s + l i t i g a t i o n + r e f o r m + a c t + o f + 1 9 9 5 % 2 c + i n c l u d i n g % 2 c + b u t + n o t + l i m i t e d + t o + t h e + c o m p a n y % 2 7 s % 3 a + % 2 8 i % 2 9 + p l a n s + t o + d e v e l o p + a n d + c o m m e r c i a l i z e + i t s + p r o d u c t + c a n d i d a t e s % 2 c + i n c l u d i n g + t h e + n e o - k i d n e y + a u g m e n t + a n d + t h e + n e o - u r i n a r y + c o n d u i t % 3 b + a n d + % 2 8 i i % 2 9 + e x p e c t a t i o n s + r e g a r d i n g + o n g o i n g + a n d + p l a n n e d + p r e c l i n i c a l + s t u d i e s + a n d + c l i n i c a l + t r i a l s + + a l t h o u g h + t e n g i o n + b e l i e v e s + t h a t + t h e s e + s t a t e m e n t s + a r e + b a s e d + u p o n + r e a s o n a b l e + a s s u m p t i o n s + w i t h i n + t h e + b o u n d s + o f + i t s + k n o w l e d g e + o f + i t s + b u s i n e s s + a n d + o p e r a t i o n s % 2 c + t h e r e + a r e + a + n u m b e r + o f + f a c t o r s + t h a t + m a y + c a u s e + a c t u a l + r e s u l t s + t o + d i f f e r + f r o m + t h e s e + s t a t e m e n t s + f o r + i n s t a n c e + t h e r e + c a n + b e + n o + a s s u r a n c e + t h a t % 3 a + % 2 8 i % 2 9 + t h e + c o m p a n y + w i l l + b e + a b l e + t o + s u c c e s s f u l l y + e n r o l l + p a t i e n t s + i n + i t s + c l i n i c a l + t r i a l s % 2 c + i n c l u d i n g + i t s + + p h a s e + 1 + c l i n i c a l + t r i a l + f o r + t h e + n e o - u r i n a r y + c o n d u i t % 3 b + % 2 8 i i % 2 9 + p a t i e n t s + e n r o l l e d + i n + t h e + c o m p a n y % 2 7 s + c l i n i c a l + t r i a l s + w i l l + n o t + e x p e r i e n c e + a d v e r s e + e v e n t s + r e l a t e d + t o + t h e + c o m p a n y % 2 7 s + p r o d u c t + c a n d i d a t e s % 2 c + w h i c h + c o u l d + d e l a y + c l i n i c a l + t r i a l s + o r + c a u s e + t h e + c o m p a n y + t o + t e r m i n a t e + t h e + d e v e l o p m e n t + o f + a + p r o d u c t + c a n d i d a t e % 3 b + % 2 8 i i i % 2 9 + t h e + r e s u l t s + o f + t h e + c l i n i c a l + t r i a l + f o r + t h e + n e o - u r i n a r y + c o n d u i t + w i l l + s u p p o r t + f u r t h e r + d e v e l o p m e n t + o f + t h a t + p r o d u c t + c a n d i d a t e % 3 b + % 2 8 i v % 2 9 + d a t a + f r o m + t h e + c o m p a n y % 2 7 s + o n g o i n g + p r e c l i n i c a l + s t u d i e s % 2 c + i n c l u d i n g + i t s + p r o p o s e d + g l p + p r o g r a m + f o r + t h e + n e o - 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