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b a s e d + p h o s p h a t e + b i n d e r % 2 c + i s + a l s o + i n + a + p h a s e + 3 + c l i n i c a l + p r o g r a m + i n + t h e + u n i t e d + s t a t e s + f o r + t h e + t r e a t m e n t + o f + h y p e r p h o s p h a t e m i a + % 2 8 e l e v a t e d + p h o s p h a t e + l e v e l s % 2 9 + i n + p a t i e n t s + w i t h + e n d - s t a g e + r e n a l + d i s e a s e + o n + d i a l y s i s % 2 c + w h i c h + i s + b e i n g + c o n d u c t e d + p u r s u a n t + t o + a + s p e c i a l + p r o t o c o l + a s s e s s m e n t + a g r e e m e n t + w i t h + t h e + f d a % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a k e r y x + h o l d s + a + w o r l d w i d e + l i c e n s e + % 2 8 e x c e p t + f o r + c e r t a i n + a s i a n + p a c i f i c + c o u n t r i e s % 2 9 + t o + z e r e n e x + f r o m + p a n i o n + % 2 6 + b f + b i o t e c h % 2 c + i n c % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a s u b l i c e n s e + a g r e e m e n t + w i t h + j a p a n + t o b a c c o + % 2 6 + t o r i i + p h a r m a c e u t i c a l % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a i n + s e p t e m b e r + 2 0 0 7 % 2 c + k e r y x + s u b l i c e n s e d + t o + j t % 2 f t o r i i + t h e + e x c l u s i v e + r i g h t s + f o r + t h e + d e v e l o p m e n t + a n d + c o m m e r c i a l i z a t i o n + o f + i t s + h y p e r p h o s p h a t e m i a + d r u g % 2 c + z e r e n e x + % 2 8 f e r r i c + c i t r a t e % 2 9 % 2 c + i n + j a p a n + t h e + l i c e n s i n g + a r r a n g e m e n t + c a l l s + f o r + j t % 2 f t o r i i + t o + p a y + t o + k e r y x + u p + t o + % 2 4 1 0 0 + m i l l i o n + i n + u p - f r o n t + l i c e n s e + f e e s + a n d + p a y m e n t s + u p o n + t h e + a c h i e v e m e n t + o f + s p e c i f i e d + m i l e s t o n e s % 2 c + o f + w h i c h + % 2 4 2 8 + m i l l i o n + h a s + b e e n + r e c e i v e d + b y + k e r y x + t o + d a t e + + i n + a d d i t i o n % 2 c + u p o n + c o m m e r c i a l i z a t i o n % 2 c + j t % 2 f t o r i i + w i l l + m a k e + r o y a l t y + p a y m e n t s + t o + k e r y x + o n + n e t + s a l e s + o f + t h e + d r u g + i n + j a p a n + j t % 2 f t o r i i + a r e + r e s p o n s i b l e + f o r + a l l + d e v e l o p m e n t + a n d + c o m m e r c i a l i z a t i o n + c o s t s + i n + j a p a n % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + k e r y x + b i o p h a r m a c e u t i c a l s % 2 c + i n c % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a k e r y x + b i o p h a r m a c e u t i c a l s + i s + f o c u s e d + o n + t h e + a c q u i s i t i o n % 2 c + d e v e l o p m e n t + a n d + c o m m e r c i a l i z a t i o n + o f + m e d i c a l l y + i m p o r t a n t + p h a r m a c e u t i c a l + p r o d u c t s + f o r + t h e + t r e a t m e n t + o f + r e n a l + d i s e a s e + a n d + c a n c e r + k e r y x + i s + d e v e l o p i n g + z e r e n e x + % 2 8 f e r r i c + c i t r a t e % 2 9 % 2 c + a n + o r a l % 2 c + f e r r i c + i r o n - b a s e d + c o m p o u n d + t h a t + h a s + t h e + c a p a c i t y + t o + b i n d + t o + p h o s p h a t e + a n d + f o r m + n o n - a b s o r b a b l e + c o m p l e x e s + t h e + p h a s e + 3 + c l i n i c a l + p r o g r a m + o f + z e r e n e x + f o r + t h e + t r e a t m e n t + o f + h y p e r p h o s p h a t e m i a + % 2 8 e l e v a t e d + p h o s p h a t e + l e v e l s % 2 9 + i n + p a t i e n t s + w i t h + e n d - s t a g e + r e n a l + d i s e a s e + i s + b e i n g + c o n d u c t e d + p u r s u a n t + t o + a + s p e c i a l + p r o t o c o l + a s s e s s m e n t + % 2 8 s p a % 2 9 + a g r e e m e n t + w i t h + t h e + f d a + + k e r y x + i s + a l s o + d e v e l o p i n g + k r x - 0 4 0 1 + % 2 8 p e r i f o s i n e % 2 9 % 2 c + w h i c h + i s + i n + p h a s e + 3 + c l i n i c a l + d e v e l o p m e n t + f o r + m u l t i p l e + m y e l o m a + k e r y x + i s + h e a d q u a r t e r e d + i n + n e w + y o r k + c i t y % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a c a u t i o n a r y + s t a t e m e n t % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a s o m e + o f + t h e + s t a t e m e n t s + i n c l u d e d + i n + t h i s + p r e s s + r e l e a s e % 2 c + p a r t i c u l a r l y + t h o s e + a n t i c i p a t i n g + f u t u r e + c l i n i c a l + t r i a l s + a n d + b u s i n e s s + p r o s p e c t s + f o r + z e r e n e x % 2 8 t m % 2 9 + % 2 8 f e r r i c + c i t r a t e % 2 9 + m a y + b e + f o r w a r d - 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