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i n f e r i o r + t o + t h e + c u r r e n t l y - a v a i l a b l e + i m m e d i a t e + r e l e a s e + c y s t e a m i n e + b i t a r t r a t e + t r e a t m e n t % 2 c + c y s t a g o n % 2 8 r % 2 9 % 2 c + t a k e n + e v e r y + 6 + h o u r s % 2 c + f o r + m a i n t e n a n c e + o f + w h i t e + b l o o d + c e l l + % 2 8 % 2 2 w b c % 2 2 % 2 9 + c y s t i n e + l e v e l s + i n + p a t i e n t s + w h o + w e r e + a l r e a d y + w e l l + c o n t r o l l e d + o n + c y s t a g o n % 2 8 r % 2 9 + t h e + c l i n i c a l + t r i a l + a l s o + s h o w e d + t h a t + r p 1 0 3 + m e t + i t s + p r i m a r y + e n d p o i n t + a t + a + l o w e r + t o t a l + d a i l y + d o s e + t h a n + c y s t a g o n % 2 8 r % 2 9 % 0 d % 0 a % 0 d % 0 a c r a i g + b + l a n g m a n % 2 c + m d % 2 c + h e a d + o f + k i d n e y + d i s e a s e s % 2 c + a n d + t h e + i s a a c + a + a b t % 2 c + m d % 2 c + p r o f e s s o r + o f + k i d n e y + d i s e a s e s + a n d + t e n u r e d + p r o f e s s o r + o f + p e d i a t r i c s % 2 c + n o r t h w e s t e r n + u n i v e r s i t y + f e i n b e r g + s c h o o l + o f + m e d i c i n e % 2 c + a n d + l e a d + a u t h o r + o f + t h e + p u b l i c a t i o n % 2 c + s a i d % 2 c + % 2 2 r p 1 0 3 + m e t + t h e + p r i m a r y + e n d p o i n t + c o m p a r e d + t o + c y s t a g o n % 2 8 r % 2 9 + a t + a + l e s s + f r e q u e n t + d o s i n g + s c h e d u l e % 2 c + a s + w e l l + a s + a + r e d u c e d + t o t a l + d a i l y + d o s e + a s + t o + t o l e r a b i l i t y % 2 c + n o n e + o f + t h e + s e v e r e + a d v e r s e + e v e n t s + r e p o r t e d + i n + t h e + s t u d y + w e r e + c o n s i d e r e d + u n e x p e c t e d % 2 c + g i v e n + t h e + s y m p t o m s + a s s o c i a t e d + w i t h + t h e + d i s e a s e + i t s e l f + t h e + n a t u r e + o f + t h e + a d v e r s e + e v e n t s + r e p o r t e d + d u r i n g + t h e + s t u d y + w a s + s i m i l a r + b e t w e e n + t h e + c y s t a g o n % 2 8 r % 2 9 + a n d + t h e + r p 1 0 3 + t r e a t m e n t + p e r i o d s % 2 2 % 0 d % 0 a % 0 d % 0 a p a t r i c e + p + r i o u x % 2 c + m d % 2 c + p h d % 2 c + c h i e f + m e d i c a l + o f f i c e r + o f + r a p t o r % 2 c + s a i d % 2 c + % 2 2 t w o + p a t i e n t s + e x p e r i e n c e d + 2 4 % 2 5 + o f + t h e + t o t a l + g a s t r o i n t e s t i n a l + % 2 8 % 2 2 g i % 2 2 % 2 9 + a d v e r s e + e v e n t s + % 2 8 % 2 2 a e s % 2 2 % 2 9 + r e c o r d e d + i n + t h e + s t u d y % 2 c + w h i c h + a c c o u n t e d + f o r + 6 0 % 2 5 + o f + t h e + d r u g - 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0 4 % 2 c + i s + o n g o i n g + w i t h + 3 8 + e n r o l l e d + p a t i e n t s + o f + t h e + o r i g i n a l + 4 1 + p a t i e n t s + w h o + c o m p l e t e d + t h e + p h a s e + 3 + c l i n i c a l + t r i a l + t h i r t y - t w o + o f + t h e + p h a s e + 3 + p a t i e n t s + h a v e + b e e n + o n + r p 1 0 3 + f o r + a t + l e a s t + 1 2 + m o n t h s + w i t h + s o m e + p a t i e n t s + n o w + a p p r o a c h i n g + 1 8 + m o n t h s + o n + r p 1 0 3 + i n + a d d i t i o n % 2 c + e n r o l l m e n t + i n + t h e + e x t e n s i o n + s t u d y + h a s + b e e n + e x p a n d e d + t o + i n c l u d e + 1 3 + c h i l d r e n + u n d e r + 6 + y e a r s + o l d % 2 c + a n d + 5 + p a t i e n t s + w i t h + a + f u n c t i o n i n g + k i d n e y + t r a n s p l a n t + t h e + c h i l d r e n + a r e + r e c e i v i n g + t h e i r + r p 1 0 3 + b y + s p r i n k l i n g + t h e + c a p s u l e + c o n t e n t s + o n t o + a p p l e s a u c e + o r + a d m i n i s t e r e d + t h r o u g h + a + g a s t r i c + t u b e + r a p t o r + p l a n s + t o + p r e s e n t + d a t a + f r o m + t h e + e x t e n s i o n + t r i a l + l a t e r + t h i s + y e a r % 0 d % 0 a % 0 d % 0 a i n + m a r c h % 2 c + 2 0 1 2 % 2 c + t h e + e u r o p e a n + m e d i c i n e s + a g e n c y + % 2 8 % 2 2 e m a % 2 2 % 2 9 + v a l i d a t e d + r a p t o r % 2 7 s + m a r k e t i n g + a u t h o r i z a t i o n + a p p l i c a t i o n + f o r + r p 1 0 3 + f o r + t h e + p o t e n t i a l + t r e a t m e n t + o f + n e p h r o p a t h i c + c y s t i n o s i s + t h e + m a a + i s + n o w + b e i n g + r e v i e w e d + b y + t h e + e m a + a l s o + i n + m a r c h % 2 c + r a p t o r + s u b m i t t e d + a + n e w + d r u g + a p p l i c a t i o n + % 2 8 % 2 2 n d a % 2 2 % 2 9 + t o + t h e + u s + f o o d + a n d + d r u g + a d m i n i s t r a t i o n + % 2 8 % 2 2 f d a % 2 2 % 2 9 + s e e k i n g + a p p r o v a l + t o + m a r k e t + r p 1 0 3 + f o r + t h e + p o t e n t i a l + t r e a t m e n t + o f + n e p h r o p a t h i c + c y s t i n o s i s + r a p t o r + r e q u e s t e d + a + p r i o r i t y + r e v i e w + o f + t h e + n d a + w h i c h % 2 c + i f + g r a n t e d + b y + f d a % 2 c + c o u l d + l e a d + t o + a + d e c i s i o n + f o r + m a r k e t i n g + a p p r o v a l + f o r + r p 1 0 3 + f o r + t h e + p o t e n t i a l + t r e a t m e n t + o f + c y s t i n o s i s + i n + t h e + u s % 2 c + i n + t h e + f o u r t h + q u a r t e r + o f + 2 0 1 2 % 0 d % 0 a % 0 d % 0 a a b o u t + n e p h r o p a t h i c + c y s t i n o s i s % 0 d % 0 a % 0 d % 0 a n e p h r o p a t h i c + c y s t i n o s i s % 2 c + a n + o r p h a n + d i s e a s e % 2 c + i s + e s t i m a t e d + t o + e f f e c t + a + p o p u l a t i o n + o f + 2 % 2 c 0 0 0 + p a t i e n t s + w o r l d w i d e % 2 c + i n c l u d i n g + 5 0 0 + p a t i e n t s + i n + t h e + u s + a n d + 8 0 0 + p a t i e n t s + i n + e u r o p e + c y s t i n o s i s + p a t i e n t s + h a v e + i n h e r i t e d + a + d e f e c t i v e + c y s t i n e + t r a n s p o r t e r + g e n e + t h a t + r e s u l t s + i n + b o d y - w i d e + c e l l u l a r + t o x i c i t y + r e s u l t i n g + f r o m + t h e + a b n o r m a l + b u i l d u p + o f + t h e + a m i n o + a c i d + c y s t i n e + i n + t h e + l y s o s o m e s + c y s t i n o s i s + i s + u s u a l l y + d i a g n o s e d + i n + t h e + f i r s t + y e a r s + o f + l i f e + a n d + r e q u i r e s + l i f e l o n g + t h e r a p y + c y s t i n e + c r y s t a l s + a c c u m u l a t e + i n + v a r i o u s + t i s s u e s + a n d + o r g a n s % 2 c + i n c l u d i n g + t h e + k i d n e y s % 2 c + b r a i n % 2 c + l i v e r % 2 c + t h y r o i d % 2 c + p a n c r e a s % 2 c + m u s c l e s + a n d + e y e s + l e f t + u n t r e a t e d % 2 c + t h e + d i s e a s e + i s + f a t a l + b y + t h e + e n d + o f + t h e + f i r s t + d e c a d e + o f + l i f e + r p 1 0 3 + r e d u c e s + c e l l u l a r + t o x i c i t y + b y + c o n t i n u o u s l y + r e m o v i n g + c y s t i n e + f r o m + t h e + l y s o s o m e % 0 d % 0 a % 0 d % 0 a a b o u t + c y s t e a m i n e + a n d + r p 1 0 3 % 0 d % 0 a % 0 d % 0 a r p 1 0 3 + i s + r a p t o r % 2 7 s + p r o p r i e t a r y % 2 c + d e l a y e d + a n d + e x t e n d e d + r e l e a s e % 2 c + o r a l + m e d i c a t i o n + d e s i g n e d + t o + p o t e n t i a l l y + t r e a t + t h e + u n d e r l y i n g + m e t a b o l i c + c a u s e + o f + c y s t i n o s i s + r p 1 0 3 + i s + a n + e n t e r i c + c o a t e d % 2 c + m i c r o b e a d + f o r m u l a t i o n + o f + c y s t e a m i n e + b i t a r t r a t e + t h a t + h a s + b e e n + f o r m u l a t e d + t o + b e + s p r i n k l e d + o n t o + f o o d + f o r + a d m i n i s t r a t i o n + t o + p a t i e n t s + t o o + y o u n g + t o + t a k e + o r a l + c a p s u l e s + a s + d e m o n s t r a t e d + i n + t h e + p h a s e + 3 + c l i n i c a l + t r i a l + d e t a i l e d + i n + t h e + p u b l i c a t i o n + i n + c j a s n % 2 c + t h e + e v e r y + 6 + h o u r + c y s t e a m i n e + d o s i n g + t r e a t m e n t + m a y + b e + r e d u c e d + s u b s t a n t i a l l y + t o + t w i c e + d a i l y + o n + r p 1 0 3 % 0 d % 0 a % 0 d % 0 a i n + d e c e m b e r + 2 0 0 7 % 2 c + r a p t o r + o b t a i n e d + a n + e x c l u s i v e % 2 c + w o r l d w i d e + l i c e n s e + f r o m + t h e + u n i v e r s i t y + o f + c a l i f o r n i a % 2 c + s a n + d i e g o + f o r + t h e + d e v e l o p m e n t + o f + r p 1 0 3 + f o r + n e p h r o p a t h i c + c y s t i n o s i s + a n d + f o r + c y s t e a m i n e + f o r + o t h e r + p o t e n t i a l + i n d i c a t i o n s + i n c l u d i n g + h u n t i n g t o n % 2 7 s + d i s e a s e % 2 c + c u r r e n t l y + i n + a + p h a s e + 2 % 2 f 3 + c l i n i c a l + t r i a l + i n + f r a n c e % 2 c + a n d + n o n - a l c o h o l i c + s t e a t o h e p a t i t i s + % 2 8 % 2 2 n a s h % 2 2 % 2 9 + c u r r e n t l y + i n + a + p h a s e + 2 b + c l i n i c a l + t r i a l + i n + t h e + u s + r a p t o r + h a s + b e e n + g r a n t e d + o r p h a n + p r o d u c t + d e s i g n a t i o n + f o r + r p 1 0 3 + f o r + t h e + p o t e n t i a l + t r e a t m e n t + o f + n e p h r o p a t h i c + c y s t i n o s i s + b y + t h e + e m a + a n d + f d a % 0 d % 0 a % 0 d % 0 a a b o u t + r a p t o r + p h a r m a c e u t i c a l + c o r p % 0 d % 0 a % 0 d % 0 a r a p t o r + p h a r m a c e u t i c a l + c o r p + r p t p + % 2 8 % 2 2 r a p t o r % 2 2 % 2 9 + s e e k s + t o + r e s e a r c h % 2 c + p r o d u c e % 2 c + a n d + d e l i v e r + m e d i c i n e s + t h a t + i m p r o v e + l i f e + f o r + p a t i e n t s + w i t h + s e v e r e % 2 c + r a r e + d i s o r d e r s + r a p t o r + c u r r e n t l y + h a s + p r o d u c t + c a n d i d a t e s + i n + c l i n i c a l + d e v e l o p m e n t + d e s i g n e d + t o + p o t e n t i a l l y + t r e a t + n e p h r o p a t h i c + c y s t i n o s i s % 2 c + n o n - a l c o h o l i c + s t e a t o h e p a t i t i s + % 2 8 % 2 2 n a s h % 2 2 % 2 9 % 2 c + h u n t i n g t o n % 2 7 s + d i s e a s e + % 2 8 % 2 2 h d % 2 2 % 2 9 % 2 c + a l d e h y d e + d e h y d r o g e n a s e + d e f i c i e n c y + % 2 8 % 2 2 a l d h 2 % 2 2 % 2 9 % 2 c + a n d + t h r o m b o t i c + d i s o r d e r % 0 d % 0 a % 0 d % 0 a r a p t o r % 2 7 s + p r e c l i n i c a l + p r o g r a m s + a r e + b a s e d + u p o n + b i o e n g i n e e r e d + n o v e l + d r u g + c a n d i d a t e s + a n d + d r u g - t a r g e t i n g + p l a t f o r m s + d e r i v e d + f r o m + t h e + h u m a n + r e c e p t o r - a s s o c i a t e d + p r o t e i n + a n d + r e l a t e d + p r o t e i n s + t h a t + a r e + d e s i g n e d + t o + t a r g e t + c a n c e r + a n d + i n f e c t i o u s + d i s e a s e s % 0 d % 0 a % 0 d % 0 a f o r + a d d i t i o n a l + i n f o r m a t i o n % 2 c + p l e a s e + v i s i t + w w w r a p t o r p h a r m a c o m % 0 d % 0 a % 0 d % 0 a t h e + r a p t o r + p h a r m a c e u t i c a l + c o r p + l o g o + i s + a v a i l a b l e + a t + h t t p % 3 a % 2 f % 2 f w w w g l o b e n e w s w i r e c o m % 2 f n e w s r o o m % 2 f p r s % 2 f % 3 f p k g i d % 3 d 7 1 8 0 % 0 d % 0 a % 0 d % 0 a % 0 9 % 0 9 % 0 9 % 0 9 % 0 9 % 0 9 f o r w a r d + l o o k i n g + s t a t e m e n t s % 0 d % 0 a t h i s + d o c u m e n t + c o n t a i n s + f o r w a r d - l o o k i n g + s t a t e m e n t s + a s + t h a t + t e r m + i s + d e f i n e d + i n + t h e + p r i v a t e + s e c u r i t i e s + l i t i g a t i o n + r e f o r m + a c t + o f + 1 9 9 5 + t h e s e + s t a t e m e n t s + r e l a t e + t o + f u t u r e + e v e n t s + o r + o u r + f u t u r e + r e s u l t s + o f + o p e r a t i o n + o r + f u t u r e + f i n a n c i a l + p e r f o r m a n c e % 2 c + i n c l u d i n g % 2 c + b u t + n o t + l i m i t e d + t o + t h e + f o l l o w i n g + s t a t e m e n t s % 3 a + t h a t + r a p t o r + w i l l + c o m p l e t e + i t s + e x t e n s i o n + t r i a l + o r + p r e s e n t + d a t a + f r o m + i t s + e x t e n s i o n + t r i a l + l a t e r + t h i s + y e a r % 3 b + t h a t + t h e + e v e r y + 6 + h o u r + c y s t e a m i n e + d o s i n g + t r e a t m e n t + w i l l + b e + r e d u c e d + t o + t w i c e + d a i l y + o n + r p 1 0 3 % 3 b + t h a t + f d a + c o u l d + r e n d e r + a + d e c i s i o n + r e g a r d i n g + m a r k e t i n g + a p p r o v a l + o f + r p 1 0 3 + f o r + t h e + p o t e n t i a l + t r e a t m e n t + o f + c y s t i n o s i s + i n + t h e + u s % 2 c + i n + t h e + f o u r t h + q u a r t e r + o f + 2 0 1 2 % 3 b + a n d + t h a t + r a p t o r + w i l l + b e + a b l e + t o + s u c c e s s f u l l y + d e v e l o p + r p 1 0 3 + o r + a n y + o f + i t s + o t h e r + p r o d u c t + c a n d i d a t e s + t h e s e + s t a t e m e n t s + a r e + o n l y + p r e d i c t i o n s + a n d + i n v o l v e + k n o w n + a n d + u n k n o w n + r i s k s % 2 c + u n c e r t a i n t i e s + a n d + o t h e r + f a c t o r s % 2 c + w h i c h + m a y + c a u s e + t h e + c o m p a n y % 2 7 s + a c t u a l + r e s u l t s + t o + b e + m a t e r i a l l y + d i f f e r e n t + f r o m + t h e s e + f o r w a r d - 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