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a s s o c i a t e d + r e n a l + v a s c u l i t i s + a r e + b e i n g + r a n d o m i z e d + i n + a + 1 % 3 a 2 + r a t i o + t o + r e c e i v e + e i t h e r + p l a c e b o + o r + 3 0 + m g + c c x 1 6 8 + t w i c e + d a i l y + f o r + a + 1 2 - w e e k + t r e a t m e n t + p e r i o d % 2 c + w i t h + a + 1 2 - w e e k + f o l l o w - u p + p e r i o d + t h e + t r i a l + i s + a s s e s s i n g + t h e + s a f e t y + a n d + t o l e r a b i l i t y + o f + c c x 1 6 8 % 2 c + a s + w e l l + a s + t h e + f e a s i b i l i t y + o f + r e d u c i n g + o r + e l i m i n a t i n g + t h e + c o n c o m i t a n t + u s e + o f + c o r t i c o s t e r o i d s + a n d + e v a l u a t i n g + t h e + e f f e c t + o f + c c x 1 6 8 + t r e a t m e n t + o n + r e n a l + f u n c t i o n + a n d + a n c a + d i s e a s e + t o + d a t e % 2 c + c c x 1 6 8 + h a s + b e e n + w e l l - t o l e r a t e d + i n + t h e + p h a s e + i i + c l i n i c a l + t r i a l % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + c 5 a r + a n d + c c x 1 6 8 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a t h e + c o m p l e m e n t + s y s t e m + c o n s i s t s + o f + a + s e t + o f + p r o t e i n s + t h a t + r e g u l a t e + c e r t a i n + t y p e s + o f + i n f l a m m a t o r y + r e s p o n s e s + + f r a g m e n t s + o f + c o m p l e m e n t + p r o t e i n s % 2 c + i n c l u d i n g + t h e + c h e m o a t t r a c t a n t + c o m p l e m e n t + f r a g m e n t + k n o w n + a s + c 5 a % 2 c + w o r k + t o + r e c r u i t + i n f l a m m a t o r y + c e l l s % 2 c + i n c l u d i n g + n e u t r o p h i l s % 2 c + t o + s i t e s + o f + i n f l a m m a t i o n + b y + m e a n s + o f + i t s + r e c e p t o r + % 2 8 c 5 a r % 2 9 + g i v e n + m o l e c u l a r + s t r u c t u r e + s i m i l a r i t i e s + b e t w e e n + t h e + c 5 a r + a n d + c h e m o k i n e + r e c e p t o r s % 2 c + c h e m o c e n t r y x + r e s e a r c h e r s + s u c c e s s f u l l y + a p p l i e d + t h e + c o m p a n y % 2 7 s + p r o p r i e t a r y + d r u g + d i s c o v e r y + t e c h n o l o g i e s + t o + t h e + d e s i g n + o f + s m a l l + m o l e c u l e + c 5 a r + i n h i b i t o r s + a n d + s e l e c t e d + c c x 1 6 8 + b a s e d + o n + i t s + p o t e n c y % 2 c + s e l e c t i v i t y + a n d + f a v o r a b l e + p h a r m a c o k i n e t i c s + c c x 1 6 8 + w a s + d i s c o v e r e d + a n d + i s + b e i n g + d e v e l o p e d + b y + c h e m o c e n t r y x + a n d + i s + t h e + f i n a l + d r u g + c a n d i d a t e + s u b j e c t + t o + o p t i o n + u n d e r + a n + a l l i a n c e + w i t h + g l a x o s m i t h k l i n e + % 2 8 g s k % 2 9 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + c h e m o c e n t r y x % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a c h e m o c e n t r y x % 2 c + i n c + i s + a + c l i n i c a l - s t a g e + b i o p h a r m a c e u t i c a l + c o m p a n y + f o c u s e d + o n + d i s c o v e r i n g % 2 c + d e v e l o p i n g + a n d + c o m m e r c i a l i z i n g + o r a l l y - a d m i n i s t e r e d + t h e r a p e u t i c s + t h a t + t a r g e t + t h e + c h e m o k i n e + a n d + c h e m o a t t r a c t a n t + s y s t e m s + i n + o r d e r + t o + t r e a t + a u t o i m m u n e + d i s e a s e s % 2 c + i n f l a m m a t o r y + d i s o r d e r s + a n d + c a n c e r + t h e + c h e m o k i n e + s y s t e m + i s + a + b i o l o g i c a l + n e t w o r k + t h a t + r e g u l a t e s + i n f l a m m a t i o n + v i a + a + c o l l e c t i o n + o f + s e c r e t e d + c h e m o k i n e + m o l e c u l e s % 2 c + o r + l i g a n d s % 2 c + a n d + t h e i r + s p e c i f i c + c e l l + s u r f a c e + r e c e p t o r s + b a s e d + o n + i t s + p r o p r i e t a r y + d r u g + d i s c o v e r y + a n d + d r u g + d e v e l o p m e n t + p l a t f o r m % 2 c + c h e m o c e n t r y x + h a s + g e n e r a t e d + m u l t i p l e + c l i n i c a l + a n d + p r e c l i n i c a l - s t a g e + p r o g r a m s % 2 c + e a c h + t a r g e t i n g + d i s t i n c t + c h e m o k i n e + a n d + c h e m o a t t r a c t a n t + r e c e p t o r s + w i t h + d i f f e r e n t + s m a l l + m o l e c u l e + c o m p o u n d s + c h e m o c e n t r y x % 2 7 s + m o s t + a d v a n c e d + d r u g + c a n d i d a t e % 2 c + v e r c i r n o n + % 2 8 a l s o + k n o w n + a s + t r a f i c e t - e n % 2 c + c c x 2 8 2 + o r + g s k 1 6 0 5 7 8 6 % 2 9 % 2 c + a + s p e c i f i c + c c r 9 + i n h i b i t o r % 2 c + c o m p l e t e d + a + m u l t i - n a t i o n a l + c l i n i c a l + t r i a l % 2 c + c a l l e d + p r o t e c t - 1 % 2 c + i n + p a t i e n t s + w i t h + m o d e r a t e - t o - s e v e r e + c r o h n % 2 7 s + d i s e a s e % 2 c + w h e r e + i t + d e m o n s t r a t e d + t h e + a b i l i t y + t o + i n d u c e + a + c l i n i c a l + r e s p o n s e + a n d + t o + m a i n t a i n + c l i n i c a l + r e m i s s i o n % 2 c + a n d + i s + n o w + i n + p h a s e + i i i + c l i n i c a l + d e v e l o p m e n t + c h e m o c e n t r y x % 2 7 s + l e a d + i n d e p e n d e n t + d r u g + c a n d i d a t e % 2 c + c c x 1 4 0 % 2 c + a + c c r 2 + i n h i b i t o r % 2 c + h a s + b e e n + s h o w n + t o + b e + s a f e + a n d + w e l l + t o l e r a t e d + w h i l e + d e m o n s t r a t i n g + c l i n i c a l + a c t i v i t y + o n + g l y c e m i c + i n d i c e s + i n + a + p h a s e + i i + c l i n i c a l + t r i a l + i n + t y p e + 2 + d i a b e t i c s % 2 c + a n d + i s + n o w + i n + p h a s e + i i + c l i n i c a l + d e v e l o p m e n t + f o r + t h e + t r e a t m e n t + o f + d i a b e t i c + n e p h r o p a t h y + o t h e r + c l i n i c a l + p r o g r a m s + i n c l u d e + c c x 3 5 4 + % 2 8 a l s o + k n o w n + a s + g s k 2 9 4 1 2 6 6 % 2 9 % 2 c + a + c c r 1 + i n h i b i t o r + w h i c h + s u c c e s s f u l l y + c o m p l e t e d + a + p h a s e + i i + c l i n i c a l + t r i a l + f o r + t h e + t r e a t m e n t + o f + r h e u m a t o i d + a r t h r i t i s % 2 c + a n d + c c x 1 6 8 % 2 c + a + c 5 a r + i n h i b i t o r + i n + p h a s e + i i + c l i n i c a l + d e v e l o p m e n t + f o r + t h e + t r e a t m e n t + o f + a n t i - n e u t r o p h i l + c y t o p l a s m i c + a n t i b o d y + % 2 8 a n c a % 2 9 - a s s o c i a t e d + v a s c u l i t i s + c h e m o c e n t r y x + a l s o + h a s + s e v e r a l + p r o g r a m s + i n + a d v a n c e d + p r e c l i n i c a l + d e v e l o p m e n t % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a f o r w a r d - l o o k i n g + s t a t e m e n t s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a c h e m o c e n t r y x + c a u t i o n s + y o u + t h a t + s t a t e m e n t s + i n c l u d e d + i n + t h i s + p r e s s + r e l e a s e + t h a t + a r e + n o t + a + d e s c r i p t i o n + o f + h i s t o r i c a l + f a c t s + a r e + f o r w a r d - l o o k i n g + s t a t e m e n t s + w o r d s + s u c h + a s + % 2 2 m a y % 2 c % 2 2 + % 2 2 c o u l d % 2 c % 2 2 + % 2 2 w i l l % 2 c % 2 2 + % 2 2 w o u l d % 2 c % 2 2 + % 2 2 s h o u l d % 2 c % 2 2 + % 2 2 e x p e c t % 2 c % 2 2 + % 2 2 p l a n % 2 c % 2 2 + % 2 2 a n t i c i p a t e % 2 c % 2 2 + % 2 2 b e l i e v e % 2 c % 2 2 + % 2 2 e s t i m a t e % 2 c % 2 2 + % 2 2 i n t e n d % 2 c % 2 2 + % 2 2 p r e d i c t % 2 c % 2 2 + % 2 2 s e e k % 2 c % 2 2 + % 2 2 c o n t e m p l a t e % 2 c % 2 2 + % 2 2 p o t e n t i a l % 2 2 + o r + % 2 2 c o n t i n u e % 2 2 + o r + t h e + n e g a t i v e + o f + t h e s e + t e r m s + o r + o t h e r + c o m p a r a b l e + t e r m i n o l o g y + a r e + i n t e n d e d + t o + i d e n t i f y + f o r w a r d - l o o k i n g + s t a t e m e n t s + t h e s e + s t a t e m e n t s + a r e + b a s e d + o n + t h e + c o m p a n y % 2 7 s + c u r r e n t + b e l i e f s + a n d + e x p e c t a t i o n s + t h e + i n c l u s i o n + o f + f o r w a r d - l o o k i n g + s t a t e m e n t s + s h o u l d + n o t + b e + r e g a r d e d + a s + a + r e p r e s e n t a t i o n + b y + c h e m o c e n t r y x + t h a t + a n y + o f + i t s + p l a n s + w i l l + b e + a c h i e v e d + a c t u a l + r e s u l t s + m a y + d i f f e r + f r o m + t h o s e + s e t + f o r t h + i n + t h i s + r e l e a s e + d u e + t o + t h e + r i s k + a n d + u n c e r t a i n t i e s + i n h e r e n t + i n + t h e + c h e m o c e n t r y x + b u s i n e s s + a n d + o t h e r + r i s k s + d e s c r i b e d + i n + t h e + c o m p a n y % 2 7 s + f i l i n g s + w i t h + t h e + s e c u r i t i e s + a n d + e x c h a n g e + c o m m i s s i o n + y o u + a r e + c a u t i o n e d + n o t + t o + p l a c e + u n d u e + r e l i a n c e + o n + t h e s e + f o r w a r d - l o o k i n g + s t a t e m e n t s % 2 c + w h i c h + s p e a k + o n l y + a s + o f + t h e + d a t e + h e r e o f % 2 c + a n d + c h e m o c e n t r y x + u n d e r t a k e s + n o + o b l i g a t i o n + t o + r e v i s e + o r + u p d a t e + t h i s + n e w s + r e l e a s e + t o + r e f l e c t + e v e n t s + o r + c i r c u m s t a n c e s + a f t e r + t h e + d a t e + h e r e o f + f u r t h e r + i n f o r m a t i o n + r e g a r d i n g + t h e s e + a n d + o t h e r + r i s k s + i s + i n c l u d e d + u n d e r + t h e + h e a d i n g + % 2 2 r i s k + f a c t o r s % 2 2 + i n + c h e m o c e n t r y x % 2 7 s + p e r i o d i c + r e p o r t s + f i l e d + w i t h + t h e + s e c u r i t i e s + a n d + e x c h a n g e + c o m m i s s i o n + % 2 8 % 2 2 s e c % 2 2 % 2 9 % 2 c + i n c l u d i n g + c h e m o c e n t r y x % 2 7 s + a n n u a l + r e p o r t + o n + f o r m + 1 0 - 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