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m a s + % 2 8 u n i v e r s i t y + o f + o k l a h o m a % 2 c + t u l s a % 2 9 % 2 c + a n d + p h a r m a c i s t + j o h n + f a n i k o s + % 2 8 b r i g h a m + a n d + w o m e n % 2 7 s + h o s p i t a l % 2 c + b o s t o n % 2 c + m a % 2 9 + + a m p e d + w i l l + b e + c o n d u c t e d + a t + f i f t e e n + s i t e s + a r o u n d + t h e + n a t i o n + + a p p r o x i m a t e l y + 1 % 2 c 0 0 0 + p a t i e n t s + a r e + e x p e c t e d + t o + b e + e n r o l l e d + o v e r + a n + e i g h t e e n - m o n t h + p e r i o d + + p a t i e n t s + w i l l + r e c e i v e + s p r i x % c 3 % 8 2 % c 2 % a e + a n d % 2 f o r + a + n a r c o t i c + f o r + t h e + m a n a g e m e n t + o f + a c u t e + p a i n + a t + t h e + t i m e + o f + d i s c h a r g e + + p a t i e n t s + w i l l + b e + f o l l o w e d + f o r + f i v e + d a y s + t o + e v a l u a t e + a + v a r i e t y + o f + o u t c o m e s % 2 c + i n c l u d i n g + p a i n + r e l i e f % 2 c + a d v e r s e + e f f e c t s % 2 c + a c t i v i t y % 2 f w o r k + p a t t e r n s % 2 c + h e a l t h c a r e + r e s o u r c e + u t i l i z a t i o n % 2 c + a n d + q u a l i t y + o f + l i f e + m e a s u r e s + + t h e + a m p e d + s t u d y + w i l l + b e + f u n d e d + b y + r e g e n c y + t h e r a p e u t i c s % 2 c + a n d + c o n d u c t e d + b y + r a d n o r + r e g i s t r y + r e s e a r c h + % 2 8 s t + d a v i d s % 2 c + p a % 2 9 + a t + t h e + 1 5 + p a r t i c i p a t i n g + e m e r g e n c y + d e p a r t m e n t s + + t h e + s t u d y + o p e n s + t o + e n r o l l m e n t + n e x t + m o n t h % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 2 2 w e + d e s i g n e d + t h i s + r e g i s t r y + t o + h e l p + u s + u n d e r s t a n d + b e t t e r + w h a t + t h e + o p t i o n s + a r e + f o r + t r e a t i n g + p a i n + a f t e r + d i s c h a r g e + f r o m + t h e + e m e r g e n c y + d e p a r t m e n t + a n d + h o w + t h e + w a y + w e + t r e a t + p a i n + i m p a c t s + t h e + t o t a l + p a t i e n t + e x p e r i e n c e + a s + t h e y + r e - e n t e r + t h e i r + l i v e s % 2 c % 2 2 + s a i d + d r + t o d d + % 2 2 t h e + e m e r g e n c y + d e p a r t m e n t % 2 c + u n f o r t u n a t e l y % 2 c + c a n + b e + a + g a t e w a y + f o r + t h e + m i s u s e + a n d + a b u s e + o f + n a r c o t i c s + + a s + e m e r g e n c y + c a r e + p r o v i d e r s % 2 c + w e + n e e d + t o + b a l a n c e + t h e + r e a l + n e e d + t o + t r e a t + a c u t e + p a i n % 2 c + b u t + a l s o + m a n a g e + o u r + r e s p o n s i b i l i t y + t o + o u r + p a t i e n t s + a n d + t h e + c o m m u n i t y + + h o p e f u l l y % 2 c + t h i s + s t u d y + w i l l + h e l p + p r o v i d e + u s + a + f r a m e w o r k + f o r + e v a l u a t i n g + a l t e r n a t i v e s + t o + n a r c o t i c s + f o r + t r e a t m e n t + o f + m o d e r a t e + t o + m o d e r a t e l y + s e v e r e + p a i n % 2 2 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a p l e a s e + s e e + i m p o r t a n t + s a f e t y + i n f o r m a t i o n + f o l l o w i n g % 2 c + i n c l u d i n g + b o x e d + w a r n i n g + f o r + a d d i t i o n a l + i n f o r m a t i o n + a b o u t + s p r i x % c 3 % 8 2 % c 2 % a e + % 2 8 k e t o r o l a c + t r o m e t h a m i n e % 2 9 + n a s a l + s p r a y + p l e a s e + v i s i t + + % 0 d % 0 a w w w s p r i x c o m + + + + % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d 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e u t i c a l s + t h r o u g h + i t s + o s t e o h e a l t h + a n d + a n i m a l + h e a l t h + d i v i s i o n s + r e s p e c t i v e l y + f o r + m o r e + i n f o r m a t i o n + o n + l u i t p o l d + o r + a n y + o f + i t s + d i v i s i o n s % 2 c + p l e a s e + v i s i t % 3 a + + % 0 d % 0 a w w w l u i t p o l d c o m + + + + % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + r e g e n c y + t h e r a p e u t i c s r e g e n c y + t h e r a p e u t i c s % 2 c + a + d i v i s i o n + o f + l u i t p o l d + p h a r m a c e u t i c a l s % 2 c + i n c % 2 c + m a r k e t s + i n n o v a t i v e + p h a r m a c e u t i c a l + p r o d u c t s + t h a t + o f f e r + m e a n i n g f u l + a l t e r n a t i v e s + t o + p a t i e n t s + a n d + t h o s e + t h a t + c a r e + f o r + t h e m + c u r r e n t l y + f o c u s e d + o n + t h e + t r e a t m e n t + o f + a c u t e + p a i n % 2 c + r e g e n c y + s e e k s + t o + p r o v i d e + f i s c a l l y + a n d + s o c i a l l y + r e s p o n s i b l e + s o l u t i o n s + t o + c h a l l e n g i n g + p r o b l e m s + f a c i n g + c u s t o m e r s + a n d + t h e + h e a l t h + c a r e + s y s t e m + f o r + m o r e + i n f o r m a t i o n % 2 c + p l e a s e + v i s i t % 3 a + + % 0 d % 0 a w w w r e g e n c y t h e r a p e u t i c s c o m + + + + % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a a b o u t + d a i i c h i + s a n k y o + t h e + d a i i c h i + s a n k y o + g r o u p + i s + d e d i c a t e d + t o + t h e + c r e a t i o n + a n d + s u p p l y + o f + i n n o v a t i v e + p h a r m a c e u t i c a l + p r o d u c t s + t o + a d d r e s s + t h e + d i v e r s i f i e d % 2 c + u n m e t + m e d i c a l + n e e d s + o f + p a t i e n t s + i n + b o t h + m a t u r e + a n d + e m e r g i n g + m a r k e t s + w h i l e + m a i n t a i n i n g + i t s + p o r t f o l i o + o f + m a r k e t e d + p h a r m a c e u t i c a l s + f o r + h y p e r t e n s i o n % 2 c + h y p e r l i p i d e m i a % 2 c + a n d + b a c t e r i a l + i n f e c t i o n s % 2 c + t h e + g r o u p + i s + e n g a g e d + i n + t h e + d e v e l o p m e n t + o f + t r e a t m e n t s + f o r + t h r o m b o t i c + d i s o r d e r s + a n d + f o c u s e d + o n + t h e + d i s c o v e r y + o f + n o v e l + o n c o l o g y + a n d + c a r d i o v a s c u l a r - m e t a b o l i c + t h e r a p i e s + f u r t h e r m o r e % 2 c + t h e + d a i i c h i + s a n k y o + g r o u p + h a s + c r e a t e d + a + % 2 2 h y b r i d + b u s i n e s s + m o d e l % 2 c % 2 2 + w h i c h + w i l l + r e s p o n d + t o + m a r k e t + a n d + c u s t o m e r + d i v e r s i t y + a n d + o p t i m i z e + g r o w t h + o p p o r t u n i t i e s + a c r o s s + t h e + v a l u e + c h a i n + f o r + m o r e + i n f o r m a t i o n % 2 c + p l e a s e + v i s i t + + % 0 d % 0 a w w w d a i i c h i s a n k y o c o m + + + + % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a i m p o r t a n t + s a f e t y + i n f o r m a t i o n % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a w a r n i n g % 3 a + l i m i t a t i o n s + o f + u s e % 2 c + g a s t r o i n t e s t i n a l % 2 c + b l e e d i n g % 2 c + c a r d i o v a s c u l a r % 2 c + a n d + r e n a l + r i s k % 0 a % 0 d % 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o f + a s t h m a % 2 c + u r t i c a r i a % 2 c + o r + o t h e r + a l l e r g i c - t y p e + r e a c t i o n s + t o + a s p i r i n % 2 c + k e t o r o l a c % 2 c + o t h e r + n s a i d s + o r + e d t a + h o w e v e r % 2 c + a n a p h y l a c t o i d + r e a c t i o n s + m a y + o c c u r + i n + p a t i e n t s + w i t h + o r + w i t h o u t + a + h i s t o r y + o f + a l l e r g i c + r e a c t i o n s + t o + a s p i r i n + o r + n s a i d s + s p r i x % c 3 % 8 2 % c 2 % a e + i s + c o n t r a i n d i c a t e d + i n + p a t i e n t s + a s + a + p r o p h y l a c t i c + a n a l g e s i c + p r i o r + t o + m a j o r + s u r g e r y % 3 b + o r + i n + l a b o r % 2 c + d e l i v e r y % 2 c + o r + n u r s i n g + m o t h e r s + b e c a u s e + o f + t h e + p o t e n t i a l + a d v e r s e + e f f e c t s + o f + p r o s t a g l a n d i n - i n h i b i t i n g + d r u g s + o n + n e o n a t e s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + 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3 % 8 2 % c 2 % a e + a n d + a s p i r i n + i s + n o t + g e n e r a l l y + r e c o m m e n d e d + b e c a u s e + o f + t h e + p o t e n t i a l + o f + i n c r e a s e d + a d v e r s e + e f f e c t s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a d o + n o t + u s e + s p r i x % c 3 % 8 2 % c 2 % a e + i n + p a t i e n t s + f o r + w h o m + h e m o s t a s i s + i s + c r i t i c a l % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a c l i n i c a l + s t u d i e s % 2 c + a s + w e l l + a s + p o s t m a r k e t i n g + o b s e r v a t i o n s % 2 c + h a v e + s h o w n + t h a t + k e t o r o l a c + c a n + r e d u c e + t h e + n a t 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2 % c 2 % a e + c o n c o m i t a n t l y + w i t h + a c e + i n h i b i t o r s + a n d % 2 f o r + a n g i o t e n s i n + i i + r e c e p t o r + a n t a g o n i s t s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a k e t o r o l a c + c a n + c a u s e + s e r i o u s + g i + a d v e r s e + e v e n t s + i n c l u d i n g + b l e e d i n g % 2 c + u l c e r a t i o n % 2 c + a n d + p e r f o r a t i o n + e l d e r l y + p a t i e n t s + a r e + a t + i n c r e a s e d + r i s k + f o r + s e r i o u s + g i + e v e n t s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a u s e + s p r i x % c 3 % 8 2 % c 2 % a e + w i t h + c a u t i o n + i n + 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m i n e % 2 9 + n a s a l + s p r a y + w i t h + t h e + e y e s + i f + e y e + c o n t a c t + o c c u r s % 2 c + w a s h + o u t + t h e + e y e + w i t h + w a t e r + o r + s a l i n e % 2 c + a n d + c o n s u l t + a + p h y s i c i a n + i f + i r r i t a t i o n + p e r s i s t s + f o r + m o r e + t h a n + a n + h o u r % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a k e t o r o l a c + c a n + c a u s e + r e n a l + i n j u r y + s p r i x % c 3 % 8 2 % c 2 % a e + n a s a l + s p r a y + s h o u l d + b e + u s e d + w i t h + c a u t i o n + i n + p a t i e n t s + w i t h + a d v a n c e d + r e n a l + d i s e a s e + o r + p a t i e n t s + a t + r i s k + f o r + r e n a l + f a i l u r e + d u e + t o + v o l u m e + d e p l e t i o n + a n d + s h o u l d + b e + u s e d + w i t h + c a u t i o n + i n + p a t i e n t s + t a k i n g + d i u r e t i c s + o r + a c e + i n h i b i t o r s + l o n g - t e r m + a d m i n i s t r a t i o n + o f + n s a i d s + h a s + r e s u l t e d + i n + r e n a l + p a p i l l a r y + n e c r o s i s + a n d + o t h e r + r e n a l + i n j u r y + s u c h + a s + i n t e r s t i t i a l + n e p h r i t i s + a n d + n e p h r o t i c + s y n d r o m e % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a n s a i d s + c a n + c a u s e + s e r i o u s + d e r m a t o l o g i c + a d v e r s e + r e a c t i o n s + s u c h + a s + e x f o l i a t i v e + d e r m a t i t i s % 2 c + s t e v e n s - j o h n s o n + s y n d r o m e % 2 c + a n d + t o x i c + e p i d e r m a l + n e c r o l y s i s % 2 c + w h i c h + c a n + b e + f a t a l + t h e s e + s e r i o u s + e v e n t s + m a y + o c c u r + w i t h o u t + w a r n i n g + s p r i x % c 3 % 8 2 % c 2 % a e + s h o u l d + b e + d i s c o n t i n u e d + i m m e d i a t e l y + i n + p a t i e n t s + w i t h + s k i n + r e a c t i o n s % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a d u r i n g + p r e g n a n c y % 2 c + u s e + o f + s p r i x % c 3 % 8 2 % c 2 % a e + b e y o n d + 3 0 + w e e k s % 2 7 + g e s t a t i o n + c a n + c a u s e + p r e m a t u r e + c l o s u r e + o f + t h e + d u c t u s + a r t e r i o s u s % 2 c + r e s u l t i n g + i n + f e t a l + h a r m + % 2 8 p r e g n a n c y + c a t e g o r y + d % 2 9 + p r i o r + t o + 3 0 + w e e k s % 2 7 + g e s t a t i o n % 2 c + s p r i x % c 3 % 8 2 % c 2 % a e + s h o u l d + b e + u s e d + d u r i n g + p r e g n a n c y + o n l y + i f + p o t e n t i a l + b e n e f i t + j u s t i f i e s + t h e + p o t e n t i a l + r i s k + t o + t h e + f e t u s + % 2 8 p r e g n a n c y + c a t e g o r y + c % 2 9 % 0 a % 0 d % 0 a % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a % 0 d % 0 a n s a i d s + c a n + l e a d + t o + o n s e t + o f + n e w + h y p e r t e n s i o n + o r + w o r s e n i n g + o f + p r e e x i s t i n g + h y p e r t e n s i o n % 2 c + e i t h e r + o f + w h i c h + m a y + c o n t r i b u t e + t o + t h e + i n c r e a s e d + i n c i d e n c e + o f + c a r d i o v a s c u l a r + e v e n t s + p a t i e n t s + t a k i n g + t h i a z i d e s + o r + l o o p + d i u r e t i c s + m a y + h a v e + i m p a i r e d + r e s p o n s e + t o + t h e s e + t h e r a p i e s + w h e n + t a k i n g + n s a i d s + f l u i d + r e t e n t i o n % 2 c + e d e m a % 2 c + r e 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