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FDA and Congress launches initiatives to deal with drug shortages. |
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AMA: The Food and Drug Administration on Feb. 21 announced that it will allow the temporary importation of Lipodox as a replacement for Doxil, a drug in critical shortage that is used to treat ovarian cancer and other illnesses. The FDA also approved a new manufacturer for methotrexate, a cancer-fighting drug in a near-shortage status.
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Mouse intestinal cells induced to secrete insulin, resulting in possible cure for type 1 diabetes. |
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Medical News Today: If insulin-producing cells in the gut did not release insulin in response to blood sugar levels they would be dangerous. However, according to the researchers, the new intestinal cells are able to release insulin in response to sugar levels as they have glucose-sensing receptors. In addition, the researchers found that the insulin produced by the intestinal cells was made in enough quantity to almost normalize blood sugar levels in otherwise diabetic mice, was released into the bloodstream, and worked the same as normal insulin.
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Botulinum toxin useful in treating overactive bladder. |
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EurekAler: "In patients treated with botulinum toxin the times of urgency dropped from six a day to less than one a day. Most excitingly, about 4 in 10 women become completely continent again after six weeks and a third were still continent again six months after treatment. The effects to start to wear off after about six months or so.
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HIPK2 linked to kidney fibrosis. |
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EurekAlert: Incorporating a systems approach allowed the Mount Sinai team to identify a target that is a regulatory protein modified during chronic disease. The high activity of HIPK2 in kidney fibrosis was not identifiable by standard methods that examine gene expression changes alone, but by modeling a network of proteins using computational systems biology, the research team was able to home in on the regulator protein, HIPK2. Now, Mount Sinai scientists can work to develop a drug intervention that inhibits the activity of HIPK2.
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New laser-based photoacoustic ultrasound diagnostic method for osteoporosis |
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EurekAlert: The new technique being developed for the purposes of assessing osteoporosis deploys, for the first time in the case of bone, laser-based photo-acoustic methods for producing ultrasound. "We direct a suitable laser beam at the surface of the skin to produce an ultrasound pulse that will propagate along the bone. This prevents contact problems during the measurement process. Furthermore, the ultrasound pulse can be easily tailored by adjusting the laser beam. This enables us to achieve a much more accurate measurement," Timonen describes.
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