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5 Reasons to Buy Keryx Pharmaceuticals - Motley Fool PDF Print

The biotech sector has long been a great hunting ground for stocks that hold explosive growth potential. According to barchart, four of the five best performing stocks over the last 10 years have been biotechs. If you were smart (or lucky) enough to purchase any one of those winners 10 years ago and held until today you would be up at least 4,500%!

Of course, finding these stocks before they become huge winners and having the temperament to hold them through think-and-thin is extremely difficult. One small cap stock that certainly appears to have explosive growth potential is Keryx Biopharmaceuticals (NASDAQ:KERX), a biotech stock with a focus on renal disease in the United States. Here are 5 reasons why Keryx could become a huge winner from here. 

1. Big U.S. opportunity
Keryx is currently a one-drug company, having received FDA approval in December, 2014 for renal drug Auryxia, which treats patients with chronic kidney disease who require dialysis.

End-stage renal disease, or ESRD, is the most severe form of chronic kidney disease. Patients with ESRD have an increased risk for heart and bone disease, and ESRD can even lead to death. These patients require constant treatment to keep their metabolic readings at acceptable levels in order to maintain their health.

Auryxia offers these patients an oral solution for controlling serum phosphorous levels. Auryxia effectively reduces serum phosphorus levels and increased ferritin, iron and transferrin saturation, which is a claim that is unique to Auryxia.

The National Kidney Foundation estimates that nearly 450,000 Americans have ERSD that requires dialysis, giving Auryxia a huge opportunity. Peak sales estimates for the drug are currently running around $1 billion in the U.S. alone. 

2. Label expansion potential
While Auryxia is currently only approved to treat patients with ESRD on dialysis, there is a potentially a much bigger market opportunity for the drug. Chronic kidney disease is very common, and the vast majority of patients do not require dialysis. The disease is classified into 5 different stages depending on kidney function, and as the disease progresses many patients develop iron deficiency anemia, or IDA, despite taking medication. An estimated 1.5 million patients in the U.S. fit this description.

Keryx has initiated a phase 3 study to see if Auryxia can help these patients better control their iron levels, and the study is on track for completing by the end of the year. If Auryxia is able to help these patients better control their iron levels, then we could see a significant expansion of the market opportunity for Auryxia.  

3. Geographic expansion
Auryxia is already approved for sale in Japan, where it is currently being marketed under the brand name Riona by marketing partner Torii Pharmaceutical, which is a subsidiary of Japan Tobacco. Keryx receives royalty payments based on net sales of Riona and could also receive $55 million in additional milestones payments if sales go well. With an estimated 280,000 patients in Japan on dialysis, the market opportunity looks huge.

Auryxia is also currently under regulatory review in Europe, under the brand name Fexeric, with an approval decision expected later this year. Keryx recently announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion for the marketing authorization of Auryxia, which is certainly a good sign for the chances of gaining European approval by the end of the year. 

4. High inside ownership and smart backing
With more than 17 million shares currently held by insiders, which accounts for more than 17% of the shares outstanding, insiders appear to have a significant equity stake in the business. With that much money on the line, you can be sure they are laser focused on making Auryxia a success.

It's also worth nothing that famed money manager Seth Klarman, founder of the wildly successful hedge fund The Baupost Group, currently owns more than 22 million shares, giving his fund a 21% stake in the firm. Seth Klarman is an extremely accomplished value investor with a terrific long term track record, so it's certainly worth noting that he finds currently sees value in the shares.

5. Strong balance sheet
After completing a share offering earlier this year, the company holds $168 million on the balance sheet and currently has no debt. While the company is still losing money, it appears to have enough capital to ramp up spending as it launches Auryxia. In addition, analysts are predicting sales around $100 million in 2016, which should help the company slow the rate of capital burn considerably, especially if sales estimates prove to be conservative.

Is Keryx a buy?
When you put these factors together, it makes Keryx look very interesting right now. The stock has been hit hard over the past year as Auryxia have been slower out of the gate than many investors were hoping for. Management believes that is mostly attributable to the current restrictive access to the drug, and they are working to correct the problem with payers, but Wall Street has soured on Keryx stock on the news. 

KERX Chart

Clinically, Auryxia looks like it could be a winner, and if the company can successfully commercialize the drug around the world then Keryx's stock could become a multi-bagger. While the opportunity looks huge, as a potential investor, I want to see a little bit more commercial success for Auryxia before I could call the stock a buy today. We won't have to wait long for an answer, as the company reports earnings tomorrow, August 5. You can bet I won't be the only one listening closely.

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MediPoint: Renal Denervation Research Report- US Analysis, Trends, opportunity ... - Medgadget.com (blog) PDF Print
MrrBiz39

The report analyzes and presents an overview of MediPoint: Renal Denervation – US Analysis And Market Forecasts worldwide.

Numerous medical device news sources and industry executives have proclaimed renal denervation to be the top medical device breakthrough of the past two years, and for good reason. Hypertension is one of the most prevalent chronic conditions worldwide, with some studies estimating that 50% of the adult population globally will have the disease in the next 20 years. With limited effectiveness from pharmacotherapy, medical device therapy has the potential for significant adoption in the treatment of resistive hypertension and uncontrolled hypertension, once efficacy and cost-effectiveness are proven. Additionally, the degree of blood pressure reduction found in long-term clinical trials from such a well-tolerated procedure has generated notable optimism about the intervention’s application in other conditions where hyperactivity of the sympathetic nervous system plays a significant role, such as congestive heart failure.

The renal denervation market in the United States will grow from essentially nothing in 2012 as the intervention was not approved for any indication in the United States in 2012. That is expected to change by the end of the forecast period in 2019. By then, the intervention is expected to be approved in both uncontrolled hypertension and resistant hypertension patients. The adoption of the procedure will be much higher in the US.

Browse Full Report With Full TOC: http://www.marketresearchreports.biz/analysis/179458

Scope

An overview of hypertension, which includes epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines.
Annualized US renal denervation market revenue and future forecasts from 2009 to 2011, forecast for 7 years to 2018.
Investigation of current and future market competition for renal denervation
Insightful review of the key industry drivers, restraints and challenges as well as predicted impact of key events.
Competitor assessment including device approval analysis and device sales forecasts.
Marketed and pipeline product profiles covering efficiency, safety, clinical study details, device approvals, product positioning and device sales forecast.
Analysis of unmet needs within the market and opportunities for future players.
Technology trends evaluation to assess strength of pipeline.
An overview of all devices in development including clinical study details, design and material selection considerations, efficacy reports, and device approval timelines.
Company profiles including business description, financial overview and SWOT analysis.
Coverage of key market players.
Strategic assessment of the renal denervation sector through market impact analysis, future market scenario and company analysis.
Direct quotes from Key Opinion Leaders (KOL) as well as cardiologists

Download The sample Copy Of This Report: http://www.marketresearchreports.biz/sample/sample/179458

Reasons to buy

Understand the trends shaping and driving the US renal denervation market.
Realize device preferences of physicians who have performed the tests already.
Access market sizing, forecasts and quantified growth opportunities in the US renal denervation market through 2018.
Quantify candidate patient populations to better design product pricing & launch plans.
Drive revenues, formulate effective sales and marketing strategies and gain in-depth understanding of the competitive landscape.
Perform benchmarking analysis of growth opportunities against currently marketed products.
Assess competitiveness of products in market by understanding the strengths and weaknesses of current competition.
Take a comprehensive look at the market’s device pipeline and identify promising, paradigm-shifting products.
Create an effective counter-strategy to gain a competitive advantage against those currently in the market.
Organize your sales and marketing efforts by identifying the market categories and segments that present the best opportunities for growth.
What’s the next big thing in US renal denervation market landscape? Identify, understand and capitalize.

Browse All Reports of In Vitro Diagnostics: http://www.marketresearchreports.biz/category/61

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MarketResearchReports.biz is the most comprehensive collection of market research reports. MarketResearchReports.Biz services are specially designed to save time and money for our clients. We are a one stop solution for all your research needs, our main offerings are syndicated research reports, custom research, subscription access and consulting services. We serve all sizes and types of companies spanning across various industries.

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Wall Street Analysts Have $21 Price Target on NxStage Medical, Inc. (NASDAQ:NXTM) - Markets Daily PDF Print

There are 4 research firms in total that have issued ratings on NxStage Medical, Inc. (NASDAQ:NXTM) within the past year. The consensus, or mean target price of the Wall Street analysts covering the firm is $21.

Analysts are predicting that NxStage Medical, Inc. (NASDAQ:NXTM) will report $-0.1 earnings per share when they next issue their quarterly earnings release on or around 2015-08-06. The consensus mean estimate is the calculated mean of all brokerage sell-side analysts that issue earnings estimates for the company. In the most recent quarter the company reported earnings of $0 that ended on 2015-03-31. NxStage Medical, Inc. (NASDAQ:NXTM) has a 2 consensus analyst rating on the stock based on an arithmetical average of the 4 ratings given by the brokerage analysts covering the company. This number is based on a 1 to 5 scale where 1 indicates a Strong Buy recommendation while 5 represents a Strong Sell. The highest estimate of the 4 covering analysts sees the stock climbing to $24 within the next year while the lowest estimate places the 12-month target price at $15. Looking ahead to full year estimates, analysts have placed the consensus earnings per share estimate for the current year at $-0.35. The most bullish analyst sees the company reporting earnings per share of $-0.31 while the most bearish analyst is predicting a current year EPS number of $-0.42. NxStage Medical, Inc. (NxStage) is a medical device company that develops, manufactures and markets products for the treatment of kidney failure, fluid overload and related blood treatments and procedures. The Company’s primary product is the NxStage System One (System One). It also sells needles and blood tubing sets primarily to dialysis clinics for the treatment of end-stage renal disease (ESRD). It operates in two segments: System One and In-Center. It distributes its products in three markets: home, critical care and in-center. In the System One segment it derives its revenues from the sale and rental of the System One and PureFlow SL equipment, and the sale of disposable products in the home and critical care markets. In the In-Center segment, it derives its revenues from the sale of blood tubing sets and needles for hemodialysis primarily for the treatment of ESRD patients at dialysis centers and needles for apheresis, which is referred to as the in-center market.

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Research and Markets: Acute Renal Failure (ARF) (Acute Kidney Injury) Pipeline ... - Business Wire (press release) PDF Print

DUBLIN--(BUSINESS WIRE)--Research and Markets (http://www.researchandmarkets.com/research/699tw6/acute_renal) has announced the addition of the "Acute Renal Failure (ARF) (Acute Kidney Injury)-Pipeline Insights" report to their offering.

Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Insights provides the in-depth analysis of the pipeline assets across the Acute Renal Failure (ARF) (Acute Kidney Injury) landscape. The main objective of this report to track competitor pipeline molecules, related research activities, technology, collaborations, in-licensing and out-licensing deals. The Acute Renal Failure (ARF) (Acute Kidney Injury) Report helps to identify emerging players with potentially strong product information and create effective counter-strategies to gain competitive advantage.

Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Insights Report covers the Acute Renal Failure (ARF) (Acute Kidney Injury) pipeline molecules at various stages of development like Pre-registration phases, clinical phases (Phase III, Phase II & Phase I), pre-clinical and discovery phases. The Report also provides Acute Renal Failure (ARF) (Acute Kidney Injury) related therapeutic assessments by molecule type, route of administration, monotherapy and combination products. The Report also highlights the discontinued and inactive projects in pipeline for Acute Renal Failure (ARF) (Acute Kidney Injury).

Scope

- The report provides a Acute Renal Failure (ARF) (Acute Kidney Injury) Landscape across the globe.

- The report provides drug profiles which includes product description, MOA, licensors & collaborators, technology, development partner and chemical information.

- Coverage of the Acute Renal Failure (ARF) (Acute Kidney Injury) pipeline on the basis of target, MOA, route of administration, technology involved and molecule type.

- The report reviews key players involved in the therapeutics development for Acute Renal Failure (ARF) (Acute Kidney Injury) and also provide company profiling.

- Pipeline products coverage based on various stages of development from NDA filings to discovery.

- Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type.

For more information visit http://www.researchandmarkets.com/research/699tw6/acute_renal

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Two dialysis centers open in Macon - Macon Telegraph PDF Print

Two dialysis centers open in Macon
Macon Telegraph
American Renal Associates LLC, in partnership with physicians of Central Georgia Kidney Specialists opened Macon Southside Dialysis Center at 2117 Eisenhower Parkway and the Dialysis Center of Macon at 890 Second St., according to a news release.

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