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IU scientists successfully transplant primary kidney cells intravenously to ... - News-Medical.net

Indiana University School of Medicine scientists have successfully transplanted primary kidney cells intravenously to treat renal failure in rats, pointing the way to a possible future alternative to kidney transplants and expensive dialysis treatments in humans.

The researchers, Katherine J. Kelly, M.D., associate professor of medicine, and Jesus Dominguez, M.D., professor of medicine, genetically modified the cells in the laboratory to produce a protein - called SAA - that plays an important role in renal cell growth, embryonic kidney development and kidney regeneration after an injury. Modified cells found their way to the appropriate locations of the damaged kidneys, resulting in regeneration of tissue and improved function in the kidney.

The researchers' work has been accepted for publication in the American Journal of Physiology - Renal Physiology, which published an advance online version of the paper on May 16.

The authors point out there is a significant and expanding need for better kidney treatments because growing numbers of people are facing progressive kidney failure due to rising incidence of diabetes, hypertension and the aging of the population.

According to the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, more than 20 million Americans have chronic kidney disease, and more than half a million people are being treated for end stage renal disease. For those patients the options are limited to dialysis or kidney transplants. Nearly 99,000 people are now on the waiting list for a kidney transplant, according to the Organ Procurement and Transplantation Network, and more than 12 people die each day while on a kidney transplant waiting list.

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Atkins-Type Diets Look Kidney-Friendly: Study - U.S. News World Report

By Kathleen Doheny
HealthDay Reporter

THURSDAY, May 31 (HealthDay News) -- High protein, Atkins-type diets don't cause noticeable harm to the kidneys in healthy patients without kidney disease, a new study indicates.

"There has been concern for decades about possible damaging effects of high-protein diets on the kidney," said Dr. Allon Friedman, an associate professor of medicine at the Indiana University School of Medicine, Indianapolis. It was thought that excess protein "can rev up the filtering mechanism in the kidney, causing damage over time," he explained.To see whether those fears were founded, Friedman and his team compared the effects on renal function of a low-carbohydrate, high-protein diet with those of a standard low-fat, calorie-restricted diet. For two years, they followed 307 obese men and women, half of whom followed the high-protein diet, and half assigned to the low-fat plan. None had kidney disease.For the high-protein diet, the researchers used guidelines from "Dr. Atkins' New Diet Revolution," which limits carbohydrates while permitting unlimited fat and protein intake. In the low-fat group, women were instructed to consume 1,200 to 1,500 calories a day, and men, 1,500 to 1,800 calories daily. They ate about 55 percent of calories from carbs, 30 percent from fat and 15 percent from protein.The researchers then measured markers of kidney function."For otherwise healthy obese people, we did not find that a low-carbohydrate, high-protein diet was dangerous to kidney heath or put people at increased risk for that two-year period," he said."One of the take-home messages is, the fact that you lose weight is more important than how you get there," Friedman added.However, it is unknown whether the results would hold longer than two years or apply to people with chronic conditions such as diabetes, high blood pressure or kidney disease, Friedman said.The study, supported by U.S. National Institutes of Health grants, is published online May 31 and in the July print issue of the Clinical Journal of the American Society of Nephrology.Weight loss was similar for both groups. By 24 months, the dieters had lost about 7 percent of body weight on average."Both groups had a drop in the protein in their urine," Friedman said. Excess protein in the urine can indicate kidney problems.Many participants dropped out before the end of the study. At two years, only 74 of the low-carb group and 83 of the low-fat group completed the blood test measurements.Connie Diekman, director of university nutrition at Washington University in St. Louis, called the study "an interesting first look at an issue of longstanding concern, high-protein diets and renal function."Still more research is needed, she said, including a study to compare a high-protein diet in healthy individuals free of kidney disease with those who have a family history of kidney problems.Because the findings don't apply to those with kidney problems, "I would caution people with a history of renal [kidney] problems about the potential impact of high protein on the health of the kidney," Diekman said.Diet plans should be developed on an individual basis, she said.The authors said longer follow-up would help determine effects on kidney function over a longer period, and Friedman said he hopes to look at the effect of high-protein diets on those who have kidney disease.The Atkins weight-loss program had no role in the study.More informationTo learn more about kidney disease, visit the National Kidney Foundation.

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Do Low-Carb Diets Damage the Kidneys? - Newswise (press release)

Popular weight loss strategy OK for the kidneys of obese individuals without kidney disease

Newswise — Washington, DC (May 31, 2012) — Low-carbohydrate, high-protein diets—like the Atkins diet—have been popular among dieters for years. For just as long, experts have worried that such diets might be harmful to the kidneys. A study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN) looks into these safety concerns.

Allon Friedman, MD, (Indiana University School of Medicine) and his colleagues compared the effects of a low-carbohydrate, high-protein diet versus a standard low-fat diet on a variety of kidney-related measures in 307 obese individuals without kidney disease over a two year period.

The researchers found that a low-carbohydrate high-protein weight loss diet did not cause noticeably harmful effects to patients’ kidney function or their fluid and electrolyte balance compared with a low-fat diet. “These results are relevant to the millions of healthy obese adults who use dieting as a weight loss strategy,” said Dr. Friedman.

The authors noted that further follow-up is needed to determine even longer-term effects of the diet on the kidneys. Additional studies should also evaluate the effects of the diet in different types of individuals, such as those with chronic kidney disease, diabetes, or hypertension, and those at increased risk of developing kidney stones.

Study co-authors include Lorraine Ogden, PhD, Gary Foster, PhD, Samuel Klein, MD, Richard Stein, PhD, Bernard Miller, MD, James Hill, PhD, Carrie Brill, Brooke Bailer, PhD, Diane Rosenbaum, and Holly Wyatt, MD.

An editorial will accompany the July 2012 print publication of this study.

Disclosures: The authors reported no financial disclosures.

The article, entitled “Comparative Effects of Low-Carbohydrate High-Protein Versus Low-Fat Diets on Kidney Function,” will appear online at http://cjasn.asnjournals.org/ on May 31, 2012, doi: 10.2215/CJN.11741111.

The content of these articles does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 13,500 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

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Polymer pills turn out lytes in chronic HF with renal disease - TheHeart.Org

TheHeart.Org
Patients with advanced HF and renal dysfunction who daily swallowed a handful of capsules containing an electrolyte- and fluid-binding polymer showed meaningful gains in symptom and functional status over eight weeks, according to researchers from the

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Low Carb Diet Does Not Hurt Kidneys in the Obese - Insidermedicine

(May 31, 2012 - Insidermedicine)

From Indiana - Low carb diets are safe for obese individuals without kidney disease, according to a report published in the Clinical Journal of the American Society of Nephrology. Randomizing over 300 obese individuals to either a low carb/high protein diet or a low fat diet for 2 years, researchers found that the low carb diet did not adversely affect the patient's kidney function or electrolyte balance.

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