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Kidneys can be recycled - News24 PDF Print
2012-04-26 09:22

Chicago - It turns out kidneys and other organs donated for transplants can be recycled.

Recently in Chicago, in what is believed to be the first documented case of its kind in the US, a transplanted kidney that was failing was removed from a patient while he was still alive and given to somebody else.

There have been other cases since the 1980s of transplant organs being used more than once, but they were rare and involved instances in which the first recipient died.

Typically, when transplanted organs fail in living patients, doctors throw them away. But with more than 73 000 people awaiting transplants nationwide, some specialists say doctors should consider trying to reuse more organs to ease the severe shortage.

"The need for kidney transplantation doesn't match our capacity," said Dr Lorenzo Gallon, a Northwestern University transplant specialist who oversaw the kidney recycling operation in Chicago. "People die on dialysis" while awaiting kidneys.

Unusual case

That was the possible fate awaiting two strangers. A research letter describing the unusual case was published in Thursday's New England Journal of Medicine.

The donated kidney lasted just two weeks in the first patient, a 27-year-old Illinois man. The same disease that ruined his kidneys started to damage the new kidney, given to him by his sister.

He was getting sicker, and doctors needed to act fast if they were going to save the organ. With permission from the man and his sister, they removed it last July and re-transplanted it into a 67-year-old Indiana man.

The Illinois man is back on dialysis and will probably get another transplant eventually.

Still, reusing a transplanted organ can be tricky - and riskier - because surgeons have to deal with scar tissue that typically forms around an organ as the body heals from the operation.

Also, Wayne Shelton, a bioethicist at Albany Medical College in New York, said the practice may raise ethical questions. He said doctors need to make sure patients who are offered reused parts understand all the risks and are not made to feel coerced into accepting such organs.

And because these cases are so rare, there is little data on how patients with recycled parts fare, Shelton noted.

Rare

Dr Jonathan Bromberg, director of transplantation at the University of Maryland Medical Centre, praised the Northwestern doctors but said organ recycling is unlikely to become commonplace because it would be rare for an already transplanted organ to be healthy enough to be reused.

In Boston in 2009, a man died shortly after a getting a new heart, and the organ was in good enough shape to be transplanted into someone else.

A 2005 medical journal report detailed three US cases involving donor livers reused after the initial recipients died, and said they were among 11 similar cases between 1987 and 2005. Medical literature also includes reports from the 1990s about a kidney re-transplant in Spain and a heart re-transplant in Switzerland.

In the Chicago case, Ray Fearing received a new kidney that was later reused by Erwin Gomez, a surgeon familiar with the medical complexities involved.

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Intensive dialysis at home could increase survival chances for patients with ESRD - News-Medical.net PDF Print

Patients suffering with end-stage renal disease could increase their survival chances by undergoing intensive dialysis at home rather than the conventional dialysis in clinics. A new study by Lawson Health Research Institute shows the potential of more intensive dialysis completed in a home setting.

The study found that patients who underwent intensive dialysis at home have better survival rates than patients who had conventional dialysis in clinics. Intensive dialysis patients also had better blood pressure results and biochemical test values than conventional dialysis patients.

Dr. Gihad Nesrallah, a Lawson researcher, led the observational study comparing at home intensive dialysis and conventional dialysis in clinics. Intensive dialysis at home consists of eight hours of treatment, three to seven nights a week. Conventional dialysis that takes place in dialysis clinics is usually conducted in less than five hours, three days per week.

Dialysis providers and governments are recognizing the benefits of home based dialysis. The Ontario Renal Network has made independent, at home dialysis a priority for funding more frequent or longer term dialysis therapy. More observational studies, such as this one are needed to further investigate why intensive dialysis at home is more beneficial to the survival of patients.

"Strategies to improve survival for persons with end-stage renal disease are needed, and more intensive dialysis represents one of the more promising options that had emerged in the last two decades. We think that patients may wish to seriously consider intensive hemodialysis where possible," said Dr. Nesrallah.

This study, along with other observational studies focusing on kidney dialysis treatment, has the potential to influence policies centered around funding and gaining more resources to help make intensive at home kidney dialysis more readily available.

Source: Lawson Health Research Institute

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Patient recovery after being declared brain dead in the news. PDF Print
Huffpost: Despite being declared brain dead by four doctors, a car crash victim has made a miracle recovery after his parents begged for a second opinion before his life support was due to be switched off, BBC News reports.

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Survey of physician salaries in 2011. PDF Print
Kaiser: The annual survey isn’t scientific – and perhaps, not surprising, either — but it offers insights into what nearly 25,000 physicians earn, and how they view that number. In 2011, compensation self-reported by surveyed physicians ranged from an average of $156,000 for pediatricians to $315,000 for radiologists and orthopedic surgeons.

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FDA issues safety warning about using aliskiren plus an ACEI or ARB in diabetes or CKD. PDF Print
FDA: FDA notified healthcare professionals of possible risks when using blood pressure medicines containing aliskiren with other drugs called angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in patients with diabetes or kidney (renal) impairment. These drug combinations should not be used (are contraindicated) in patients with diabetes. In addition, avoid use of aliskiren with ARBs or ACEIs in patients with moderate to severe renal impairment (i.e., where glomerular filtration rate [GFR] < 60 mL/min). The labels for the aliskiren drugs are being updated based on preliminary data from a clinical trial, “Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE).”

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