Orexin is a hormone that fights (white) fat with (brown) fat. Are obese persons orexin-deficient? PDF Print
EurekAlert: "Our study provides a possible reason why some people are overweight or obese despite the fact that they don't overeat—they might lack the orexin necessary to activate brown fat and increase energy expenditure," explained Devanjan Sikder, D.V.M, Ph.D., senior author of the study and assistant professor in Sanford-Burnham's Diabetes and Obesity Research Center, located in Orlando's Medical City at Lake Nona.

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