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Stories from the dialysis comunity across the globe.
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CKD patients have reduced ability to prevent vascular calcification. |
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EurekAlert (JASN): Now Andreas Pasch, MD (University Hospital and University of Bern, Inselspital, in Switzerland) and his colleagues have developed the first test capable of measuring the propensity for calcification to occur in blood. Using their new assay, the investigators found that both the blood of mice deficient in a protein that inhibits calcification and the blood of CKD patients on dialysis had a reduced ability to inhibit calcification. Blood from healthy volunteers did not.
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Anti-PLA2R antibodies detected in 70% of patients with idiopathic membranous GN |
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EurekAlert (JASN): Among the major findings: .... 74% of patients tested positive for antiPLA2R antibodies by IIFT and 72% tested positive by ELISA. .... Concordance between both tests was excellent, with 94% agreement. .... Antibody levels significantly correlated with the severity of patients' disease. .... Spontaneous remissions occurred much less frequently among patients with high antibody levels (38% versus 4% in the lowest and highest groups, respectively).
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ESRD program being examined as a model for cost-cutting in the Medicare system. |
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Brown University: Amid a presidential campaign and facing the “fiscal cliff,” Americans hear a lot about federal spending, particularly for Medicare. But few probably know of either the history or the present watershed moment in the program’s 40-year struggle to contain costs and finance quality treatment for Americans with end-stage renal disease. In a timely new paper in the September edition of the journal Health Affairs, researchers chronicle the history of how Medicare has provided one of its most costly services, and point out that a new strategy, if successful, could become a fiscal model for the entire program.
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Researchers decipher manic gene. |
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EurekAlert: Using the patients' detailed clinical data, the researchers tested statistically which of the symptoms are especially closely related to the NCAN gene. "Here it became obvious that the NCAN gene is very closely and quite specifically correlated with the manic symptoms," says Prof. Dr. Marcella Rietschel from the Central Institute of Mental Health in Mannheim. According to the data the gene is, however, not responsible for the depressive episodes in bipolar disorder.
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Junk DNA turns out to play a major role in cell regulation. |
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NY Times: Now scientists have discovered a vital clue to unraveling these riddles. The human genome is packed with at least four million gene switches that reside in bits of DNA that once were dismissed as “junk” but that turn out to play critical roles in controlling how cells, organs and other tissues behave. The discovery, considered a major medical and scientific breakthrough, has enormous implications for human health because many complex diseases appear to be caused by tiny changes in hundreds of gene switches.
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