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Arch Scientists Use 'BORG' Peptides to Improve Biocompatibilty of Polysulfone ... - MarketWatch PDF Print

TORONTO, ONTARIO, Jul 23, 2015 (Marketwired via COMTEX) -- Arch Biopartners Inc (Arch) or (the Company)(ACH) FOIFF, +34.63% announced today that Arch scientists have published details of their new technology and its potential applications in the area of dialysis.

Arch scientists Daniel Muruve, Randall Irvin and Elisabeth Davis have successfully applied proprietary Arch peptides to the surface of polysulfone to make it more compatible with the human blood. Polysulfone is a common polymer used in the manufacturing of dialysis membranes.

The exposure of blood to polysulfone during dialysis triggers leukocyte activation and protein absorption that contribute to blood clotting and inflammation. The Arch team has developed a single step, post manufacturing method for modifying the surface of polysulfone and other materials used for dialysis. The resulting, new biomaterial reduces the surface absorption of proteins and leukocyte activation and has potential benefit for patients undergoing dialysis or those using other bio-incompatible medical devices.

Details of these findings are reported in the ASAIO Journal. The publication, titled "Peptide-mediated PEGylation of polysulfone reduces protein absorption and leukocyte activation" by Davis, Platnich, Irvin and Muruve can be found at http://www.ncbi.nlm.nih.gov/pubmed/26181712 until it is assigned to a specific issue of the journal.

Arch plans to advance the technology further by developing a clinical prototype and producing efficacy data in-vivo, and eventually with patients in dialysis clinics.

"The data produced by our scientists shows the potential to solve a major complication for patients in dialysis treatment, and validates our BORG Peptide platform in medical devices. It adds to our growing pipeline, which includes MetaMx and ABP569" said Andrew Bishop, a director of Arch.

Dialysis and End-Stage Kidney Disease

Patients with end-stage kidney disease require life sustaining dialysis treatments. Patients on dialysis experience significant complications not only from their disease but also related to the dialysis procedure itself. Hemodialysis involves the filtering of patient's blood to remove toxins and electrolytes that accumulate as a result of kidney failure. Specialized pumps and tubing in hemodialysis machines remove blood from the patient, deliver it to semipermeable dialysis membranes where the filtering occurs and then return it to the patient. Dialysis membranes are commonly manufactured using polysulfone. The contact of patient blood to these artificial surfaces, including the polysulfone dialysis membranes activates the clotting system as well as the immune system. As a result, patients with end-stage kidney diseases suffer from chronic inflammation and require regular blood thinners that increase the risk of bleeding complications.

About Arch Biopartners

Arch Biopartners is a portfolio based biotechnology company established to develop new products and technology for unmet medical needs. The Company's portfolio includes MetaMx, which targets brain tumor initiating cells; ABP569, a new treatment for respiratory Pseudomonas aeruginosa infections; and, Metablok, a treatment for sepsis and cancer metastasis.

For more information on the Company, please consult the other public documents filed on SEDAR at www.sedar.com .

The Company has 53,189,679 common shares outstanding.

Forward-Looking Statements

All statements, other than statements of historical fact, in this news release are forward looking statements that involve various risks and uncertainties, including, without limitation, statements regarding the future plans and objectives of the Company. There can be no assurance that such statements will prove to be accurate. Actual results and future events could differ materially from those anticipated in such statements. These and all subsequent written and oral forward-looking statements are based on the estimates and opinions of management on the dates they are made and are expressly qualified in their entirety by this notice. The Company assumes no obligation to update forward-looking statements should circumstances or management's estimates or opinions change.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Contacts:
Andrew Bishop
Arch Biopartners Inc.
(647) 428 7031

 This e-mail address is being protected from spambots. You need JavaScript enabled to view it
 



SOURCE: Arch Biopartners Inc.



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Arch Scientists Use 'BORG' Peptides to Improve Biocompatibilty of Polysulfone ... - CNNMoney PDF Print

Arch Biopartners Inc (Arch) or (the Company)(TSX VENTURE:ACH) (OTCBB:FOIFF) announced today that Arch scientists have published details of their new technology and its potential applications in the area of dialysis.

Arch scientists Daniel Muruve, Randall Irvin and Elisabeth Davis have successfully applied proprietary Arch peptides to the surface of polysulfone to make it more compatible with the human blood. Polysulfone is a common polymer used in the manufacturing of dialysis membranes.

The exposure of blood to polysulfone during dialysis triggers leukocyte activation and protein absorption that contribute to blood clotting and inflammation. The Arch team has developed a single step, post manufacturing method for modifying the surface of polysulfone and other materials used for dialysis. The resulting, new biomaterial reduces the surface absorption of proteins and leukocyte activation and has potential benefit for patients undergoing dialysis or those using other bio-incompatible medical devices.

Details of these findings are reported in the ASAIO Journal. The publication, titled "Peptide-mediated PEGylation of polysulfone reduces protein absorption and leukocyte activation" by Davis, Platnich, Irvin and Muruve can be found at http://www.ncbi.nlm.nih.gov/pubmed/26181712 until it is assigned to a specific issue of the journal.

Arch plans to advance the technology further by developing a clinical prototype and producing efficacy data in-vivo, and eventually with patients in dialysis clinics.

"The data produced by our scientists shows the potential to solve a major complication for patients in dialysis treatment, and validates our BORG Peptide platform in medical devices. It adds to our growing pipeline, which includes MetaMx and ABP569" said Andrew Bishop, a director of Arch.

Dialysis and End-Stage Kidney Disease

Patients with end-stage kidney disease require life sustaining dialysis treatments. Patients on dialysis experience significant complications not only from their disease but also related to the dialysis procedure itself. Hemodialysis involves the filtering of patient's blood to remove toxins and electrolytes that accumulate as a result of kidney failure. Specialized pumps and tubing in hemodialysis machines remove blood from the patient, deliver it to semipermeable dialysis membranes where the filtering occurs and then return it to the patient. Dialysis membranes are commonly manufactured using polysulfone. The contact of patient blood to these artificial surfaces, including the polysulfone dialysis membranes activates the clotting system as well as the immune system. As a result, patients with end-stage kidney diseases suffer from chronic inflammation and require regular blood thinners that increase the risk of bleeding complications.

About Arch Biopartners

Arch Biopartners is a portfolio based biotechnology company established to develop new products and technology for unmet medical needs. The Company's portfolio includes MetaMx, which targets brain tumor initiating cells; ABP569, a new treatment for respiratory Pseudomonas aeruginosa infections; and, Metablok, a treatment for sepsis and cancer metastasis.

For more information on the Company, please consult the other public documents filed on SEDAR at www.sedar.com .

The Company has 53,189,679 common shares outstanding.

Forward-Looking Statements

All statements, other than statements of historical fact, in this news release are forward looking statements that involve various risks and uncertainties, including, without limitation, statements regarding the future plans and objectives of the Company. There can be no assurance that such statements will prove to be accurate. Actual results and future events could differ materially from those anticipated in such statements. These and all subsequent written and oral forward-looking statements are based on the estimates and opinions of management on the dates they are made and are expressly qualified in their entirety by this notice. The Company assumes no obligation to update forward-looking statements should circumstances or management's estimates or opinions change.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Research and Markets: End-Stage Kidney Disease (End-Stage Renal Disease or ... - Digital Journal PDF Print
DUBLIN--(Business Wire)--Research and Markets (http://www.researchandmarkets.com/research/kgq5kw/endstage_kidney) has announced the addition of the "End-Stage Kidney Disease (End-Stage Renal Disease or ESRD)-Pipeline Insights" report to their offering.

End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) - Pipeline Insights provides the in-depth analysis of the pipeline assets across the End-Stage Kidney Disease (End-Stage Renal Disease or ESRD). The main objective of this report to track competitor pipeline molecules, related research activities, technology, collaborations, in-licensing and out-licensing deals. The End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) Report helps to identify emerging players with potentially strong product information and create effective counter-strategies to gain competitive advantage.

End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) - Pipeline Insights Report covers the End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) pipeline molecules at various stages of development like Pre-registration phase, clinical phases (Phase III, Phase II & Phase I), pre-clinical and discovery phases. The Report also provides End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) related therapeutic assessments by molecule type, route of administration, monotherapy and combination products. The Report also highlights the discontinued and inactive projects in pipeline for End-Stage Kidney Disease (End-Stage Renal Disease or ESRD).

Scope

- The report provides a End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) Landscape across the globe

- The report provides drug profiles which includes product description, MOA, licensors & collaborators, technology, development partner and chemical information

- Coverage of the End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) pipeline on the basis of target, MOA, route of administration, technology involved and molecule type

- The report reviews key players involved in the therapeutics development for End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) and also provide company profiling

- Pipeline products coverage based on various stages of development from NDA filings to discovery.

- Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type

For more information visit http://www.researchandmarkets.com/research/kgq5kw/endstage_kidney

Research and Markets
Laura Wood, Senior Manager
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
For E.S.T Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call 1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
U.S. Fax: 646-607-1907
Fax (outside U.S.): +353-1-481-1716
Sector: Pharmaceuticals

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Authentidate's Telehealth Solution Featured in Nephrology News Issues(R) - Nasdaq PDF Print

Authentidate's Telehealth Solution Featured in Nephrology News & Issues(R)
Nasdaq
(Nasdaq:ADAT), a provider of web-based revenue cycle management applications and telehealth products and services for healthcare organizations was featured this month in an article in Nephrology News & Issues®, a publication that integrates the ...

and more »

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Authentidate's Telehealth Solution Featured in Nephrology News Issues(R ... - Nasdaq PDF Print

Authentidate's Telehealth Solution Featured in Nephrology News & Issues(R ...
Nasdaq
(Nasdaq:ADAT), a provider of web-based revenue cycle management applications and telehealth products and services for healthcare organizations was featured this month in an article in Nephrology News & Issues®, a publication that integrates the ...

and more »

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