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Stories from the dialysis comunity across the globe.



iPS cells effective in easing renal failure - The Japan News PDF Print

Jiji PressKYOTO (Jiji Press) — A group of researchers has succeeded in containing the symptoms of acute renal failure in mice by transplanting renal precursor cells made from human induced pluripotent stem, or iPS, cells, into the animals.

The achievement by the team of scientists from entities including Kyoto University’s Center for iPS Cell Research and Application, or CiRA, and Astellas Pharma Inc. was published in the online edition of U.S. science journal Stem Cells Translational Medicine on Tuesday. This method could also be effective in easing acute renal failure in human patients, according to the team.

In acute renal failure, the functions of kidneys deteriorate rapidly, in several hours to several days, due to a lack of blood or side effects of drugs. In Japan, about 5 percent of inpatients develop acute renal failure, and more than half of them die. Even survivors’ kidneys can be seriously damaged, and their disease can become chronic.Speech

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DSI Renal Expands Presence in Georgia with New Clinic in Social Circle ... - GlobeNewswire (press release) PDF Print

SOCIAL CIRCLE, Ga., July 21, 2015 (GLOBE NEWSWIRE) -- DSI Renal, a leading provider of dialysis services for patients suffering from chronic kidney failure, will hold a grand opening and ribbon cutting ceremony at its brand new dialysis clinic in Social Circle, Georgia, on July 23rd at 5:00pm.

The Mayor of Social Circle, Hal Dally, is scheduled to participate in the official ribbon cutting. "It is my pleasure to officially welcome DSI to the city of Social Circle and show my appreciation for choosing our city as the location for their newest clinic."  Said Mayor Dally.  "The addition of the new clinic will further compliment the city's current medical facilities while providing a great opportunity to better serve area residents with accessible dialysis care." Along with Mayor Dally, physicians of Eastside Premier Nephrology, DSI's clinic staff and members of DSI's Executive leadership team will also be in attendance.

"We have an important responsibility to our patients to provide access to the high-quality and compassionate care they depend on, right within their community." Said Ekundayo Falase, M.D., Medical Director, DSI Social Circle.  "Opening up this brand new dialysis facility in Social Circle, helps us to deliver on that."

The new state-of-the art facility opening follows a recent acquisition of 5 dialysis clinics in the Macon area, bringing the total number of DSI clinics in Georgia to 17.  DSI Social Circle offers in-center hemodialysis as well as home hemodialysis and peritoneal dialysis (PD) treatment options.  The patient-centered design features thoughtful amenities to ensure a comfortable dialysis experience.

"This new location is just another step towards helping those suffering from ESRD have convenient access to the life-sustaining treatment they need." Said Craig Goguen, President and Chief Operating Officer, DSI Renal.  "Expanding our services to provide care where our patients live significantly reduces travel time to and from treatments and further proves our commitment to improving the quality of life for our patients."

Members of the community and news media are invited to attend the grand opening ceremony at DSI Social Circle, located at 1032 Bateman Dr Social Circle, GA.  A free open house is scheduled from 4:00pm-7:00pm, with the official ribbon cutting taking place at 5:00pm.  Clinic staff will be available to answer questions and provide tours of the facility.
 
About DSI Renal

DSI Renal (formed as Dialysis Newco, Inc.) is a leading provider of dialysis services in the United States, offering state-of-the-art treatment for patients suffering from chronic kidney failure and renal disease.  Together with its physician partners, DSI Renal owns and operates 100 dialysis clinics in 22 states.  The company plans for growth through acquisition and development of new clinics as well as through establishment of additional joint venture partnerships with leading nephrologists for the clinic, hospital and alternate settings.  For more information, please visit www.dsi-corp.com.

Corporate Contact:
Sarah Ferry - DSI Renal
(615) 777-8200


Clinic  Contact:
Michelle Walters - Clinic Manager
(770) 464-4470

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7 Michigan hospitals named to national best list - Detroit Free Press - Detroit Free Press PDF Print

3 children's hospitals also make magazine's annual list aimed at helping patients find good care.

635730697330291552-3dsurgery-071310-aj016 Buy Photo

Seven Michigan hospitals ranked nationally on U.S. News and World Report's new Best Hospitals list.(Photo: Detroit Free Press)Buy Photo

Seven Michigan hospitals and their specialties are ranked nationally in the U.S. News & World Report's new Best Hospitals report.

Topping the list is the University of Michigan Hospitals and Health Centers with 11 nationally ranked specialties and Beaumont Hospital in Royal Oak with nine. Spectrum Health in Grand Rapids, Munson Medical Center in Traverse City, Mercy Health St. Mary's Hospital in Grand Rapids, Henry Ford Hospital and Harper University Hospital each had one nationally ranked specialty.

Related:Michigan ranked 11th-best state for doctors

Three children's hospitals in the state — U-M C.S. Mott Children's Hospital, Children's Hospital of Michigan and Spectrum Health Helen DeVos Children's Hospital in Grand Rapids — ranked nationally for several pediatric specialties.

The rankings are meant to help patients with life-threatening or rare conditions identify hospitals that excel in treating the most difficult cases, U.S. News and World Reports said. The Best Hospitals includes "consumer-friendly data and information on nearly 5,000 medical centers nationwide." You can search hospitals at http://health.usnews.com/best-hospitals.

No Michigan hospitals made the nationwide top 15 honor roll. To get on that list, hospitals needed very high scores in at least six specialties. The best hospitals in the U.S. are Massachusetts General Hospital in Boston, the Mayo Clinic in Rochester, Minn., and Johns Hopkins Hospital in Baltimore.

The seven hospitals in Michigan with their nationally ranked specialties are:

? U-M Hospitals and Health Centers: Cancer (28), cardiology and heart surgery (31), diabetes and endocrinology (36), ear, nose and throat (13), geriatrics (46), gynecology (42), nephrology (25), neurology and neurosurgery (35), ophthalmology (10), pulmonology (15) and urology (10)

? Beaumont Hospital: Cardiology and heart surgery (22), diabetes and endocrinology (17), gastroenterology and GI surgery (18), geriatrics (23), gynecology (40), nephrology (37), neurology and neurosurgery (25), orthopedics (16) and pulmonology (22)

? Spectrum Health: Pulmonology (27)

? Munson Medical Center: Diabetes and endocrinology (49)

? Mercy Health St. Mary's Hospital: Pulmonology (50)

? Henry Ford Hospital: Neurology and neurosurgery (46)

? Harper University Hospital: Neurology and neurosurgery (45)

According to the Best Hospitals report, 137 — or less than 3% — hospitals across the country were ranked nationally in at least one specialty.

The Michigan children's hospitals and their specialties that are cited nationally are:

? U-M C.S. Mott Children's Hospital: Cancer (39), cardiology and heart surgery (6), diabetes and endocrinology (38), gastroenterology and GI surgery (19), neonatology (22), nephrology (28), neurology and neurosurgery (33), orthopedics (25), pulmonology (25) and urology (38)

? Children's Hospital of Michigan: Cancer (32), cardiology and heart surgery (42), gastroenterology and GI surgery (34), nephrology (27), neurology and neurosurgery (24), orthopedics (30), pulmonology (36) and urology (42)

? Spectrum Health Helen DeVos Children's Hospital: Cancer (36), nephrology (49) and pulmonology (42)

The regionally ranked hospitals in Michigan are Beaumont Hospital in Troy, Bronson Methodist Hospital in Kalamazoo, McLaren Northern Michigan Hospital in Petoskey, St. Joseph Mercy Oakland, Sinai-Grace Hospital, Borgess Medical Center in Kalamazoo, Henry Ford Wynadotte Hospital, Marquette General Hospital, Beaumont Hospital in Grosse Pointe, McLaren Greater Lansing Hospital, Oaklawn Hospital in Marshall, Providence Hospital, St. John Hospital and Medical Center, Sparrow Hospital in Lansing, DMC Detroit Receiving Hospital and Oakwood Hospital and Medical Center.

Regional rankings take into account hospital's national rankings as we

ll as how they handled five common care areas, including hip and knee replacement surgery, heart bypass surgery, heart failure and the chronic lung disease COPD, U.S. News and World report said.

Contact Zlati Meyer: 313-223-4439 or This e-mail address is being protected from spambots. You need JavaScript enabled to view it . Follow her on Twitter @ZlatiMeyer

Read or Share this story: http://on.freep.com/1MFwvdH

...

 
7 Michigan hospitals named to national best list - Detroit Free Press PDF Print

3 children's hospitals also make magazine's annual list aimed at helping patients find good care.

635730697330291552-3dsurgery-071310-aj016 Buy Photo

Seven Michigan hospitals ranked nationally on U.S. News and World Report's new Best Hospitals list.(Photo: Detroit Free Press)Buy Photo

Seven Michigan hospitals and their specialties are ranked nationally in the U.S. News & World Report's new Best Hospitals report.

Topping the list is the University of Michigan Hospitals and Health Centers with 11 nationally ranked specialties and Beaumont Hospital in Royal Oak with nine. Spectrum Health in Grand Rapids, Munson Medical Center in Traverse City, Mercy Health St. Mary's Hospital in Grand Rapids, Henry Ford Hospital and Harper University Hospital each had one nationally ranked specialty.

Related:Michigan ranked 11th-best state for doctors

Three children's hospitals in the state — U-M C.S. Mott Children's Hospital, Children's Hospital of Michigan and Spectrum Health Helen DeVos Children's Hospital in Grand Rapids — ranked nationally for several pediatric specialties.

The rankings are meant to help patients with life-threatening or rare conditions identify hospitals that excel in treating the most difficult cases, U.S. News and World Reports said. The Best Hospitals includes "consumer-friendly data and information on nearly 5,000 medical centers nationwide." You can search hospitals at http://health.usnews.com/best-hospitals.

No Michigan hospitals made the nationwide top 15 honor roll. To get on that list, hospitals needed very high scores in at least six specialties. The best hospitals in the U.S. are Massachusetts General Hospital in Boston, the Mayo Clinic in Rochester, Minn., and Johns Hopkins Hospital in Baltimore.

The seven hospitals in Michigan with their nationally ranked specialties are:

? U-M Hospitals and Health Centers: Cancer (28), cardiology and heart surgery (31), diabetes and endocrinology (36), ear, nose and throat (13), geriatrics (46), gynecology (42), nephrology (25), neurology and neurosurgery (35), ophthalmology (10), pulmonology (15) and urology (10)

? Beaumont Hospital: Cardiology and heart surgery (22), diabetes and endocrinology (17), gastroenterology and GI surgery (18), geriatrics (23), gynecology (40), nephrology (37), neurology and neurosurgery (25), orthopedics (16) and pulmonology (22)

? Spectrum Health: Pulmonology (27)

? Munson Medical Center: Diabetes and endocrinology (49)

? Mercy Health St. Mary's Hospital: Pulmonology (50)

? Henry Ford Hospital: Neurology and neurosurgery (46)

? Harper University Hospital: Neurology and neurosurgery (45)

According to the Best Hospitals report, 137 — or less than 3% — hospitals across the country were ranked nationally in at least one specialty.

The Michigan children's hospitals and their specialties that are cited nationally are:

? U-M C.S. Mott Children's Hospital: Cancer (39), cardiology and heart surgery (6), diabetes and endocrinology (38), gastroenterology and GI surgery (19), neonatology (22), nephrology (28), neurology and neurosurgery (33), orthopedics (25), pulmonology (25) and urology (38)

? Children's Hospital of Michigan: Cancer (32), cardiology and heart surgery (42), gastroenterology and GI surgery (34), nephrology (27), neurology and neurosurgery (24), orthopedics (30), pulmonology (36) and urology (42)

? Spectrum Health Helen DeVos Children's Hospital: Cancer (36), nephrology (49) and pulmonology (42)

The regionally ranked hospitals in Michigan are Beaumont Hospital in Troy, Bronson Methodist Hospital in Kalamazoo, McLaren Northern Michigan Hospital in Petoskey, St. Joseph Mercy Oakland, Sinai-Grace Hospital, Borgess Medical Center in Kalamazoo, Henry Ford Wynadotte Hospital, Marquette General Hospital, Beaumont Hospital in Grosse Pointe, McLaren Greater Lansing Hospital, Oaklawn Hospital in Marshall, Providence Hospital, St. John Hospital and Medical Center, Sparrow Hospital in Lansing, DMC Detroit Receiving Hospital and Oakwood Hospital and Medical Center.

Regional rankings take into account hospital's national rankings as we

ll as how they handled five common care areas, including hip and knee replacement surgery, heart bypass surgery, heart failure and the chronic lung disease COPD, U.S. News and World report said.

Contact Zlati Meyer: 313-223-4439 or This e-mail address is being protected from spambots. You need JavaScript enabled to view it . Follow her on Twitter @ZlatiMeyer

Read or Share this story: http://on.freep.com/1MFwvdH

...

 
PD-1 Inhibition in Advanced Renal Cell Carcinoma - OncLive - OncLive PDF Print

Immune checkpoints are involved in pathways that disable activated T-cells so they do not overreact against the body, states David F. McDermott, MD. Inhibition of targets on the surface of T-cells, such as CTLA-4 and PD-1, can reactivate T-cells and allow them to eliminate cancers more effectively, explains McDermott.

Studies have shown encouraging improvements in response, progression-free survival (PFS), and overall survival (OS) with the use of CTLA-4 and PD-1 blocking antibodies compared with standard therapies across a variety of tumor types, including in renal cell carcinoma (RCC). Not only are these novel agents more effective than standard therapies they are also more tolerable, even when compared with older forms of immunotherapy like iinterleukin-2, adds McDermott.

Individuals with tumors that express high levels of PD-L1 may have a greater response to anti-PD-1 therapy, comments Thomas Hutson, DO, PharmD, noting that there may not be a direct correlation between PD-L1 expression and response to therapy. PD-L1 is an inducible marker that appears when T-cells recognize the tumor and may, therefore, not be present on every tumor, observes McDermott. It is also not a stable marker and may be affected by several variables, such as remaining in storage for a long period of time.

The PD-1 inhibitor nivolumab has been evaluated in clinical trials for patients with advanced RCC. Phase I data showed that nivolumab is well tolerated, although patients need to be monitored for pneumonitis, states Eric Jonasch, MD. Phase II results revealed that some patients had prolonged and persistent responses to nivolumab. Additionally, top-line findings from the pivotal phase III CheckMate-025 study revealed that nivolumab improved OS compared with everolimus for patients with metastatic RCC. Following this initial analysis, the study is being unblinded and patients in the everolimus arm will be allowed to cross over to receive nivolumab.

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